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3R4S
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CELL ENTRY OF BOTULINUM NEUROTOXIN TYPE C IS DEPENDENT UPON INTERACTION WITH TWO GANGLIOSIDE MOLECULES
Descriptor:Botulinum neurotoxin type C1, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, O-SIALIC ACID
Authors:Strotmeier, J., Gu, S., Jutzi, S., Mahrhold, S., Zhou, J., Pich, A., Bigalke, H., Rummel, A., Jin, R., Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
3R4U
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CELL ENTRY OF BOTULINUM NEUROTOXIN TYPE C IS DEPENDENT UPON INTERACTION WITH TWO GANGLIOSIDE MOLECULES
Descriptor:Botulinum neurotoxin type C1
Authors:Strotmeier, J., Gu, S., Jutzi, S., Mahrhold, S., Zhou, J., Pich, A., Bigalke, H., Rummel, A., Jin, R., Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
1T3A
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CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE E CATALYTIC DOMAIN
Descriptor:neurotoxin type E, ZINC ION, CHLORIDE ION
Authors:Agarwal, R., Eswaramoorthy, S., Kumaran, D., Binz, T., Swaminathan, S.
Deposit date:2004-04-26
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212-->Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway
Biochemistry, 43, 2004
1T3C
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CLOSTRIDIUM BOTULINUM TYPE E CATALYTIC DOMAIN E212Q MUTANT
Descriptor:neurotoxin type E, ZINC ION, CHLORIDE ION
Authors:Agarwal, R., Eswaramoorthy, S., Kumaran, D., Binz, T., Swaminathan, S.
Deposit date:2004-04-26
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212-->Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway
Biochemistry, 43, 2004
1YVG
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STRUCTURAL ANALYSIS OF THE CATALYTIC DOMAIN OF TETANUS NEUROTOXIN
Descriptor:Tetanus toxin, light chain, ZINC ION
Authors:Rao, K.N., Kumaran, D., Binz, T., Swaminathan, S.
Deposit date:2005-02-15
Release date:2005-03-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of the catalytic domain of tetanus neurotoxin.
Toxicon, 45, 2005
1ZKW
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CRYSTAL STRUCTURE OF ARG347ALA MUTANT OF BOTULINUM NEUROTOXIN E CATALYTIC DOMAIN
Descriptor:botulinum neurotoxin type E, ZINC ION, CHLORIDE ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-05-04
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
1ZKX
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CRYSTAL STRUCTURE OF GLU158ALA/THR159ALA/ASN160ALA- A TRIPLE MUTANT OF CLOSTRIDIUM BOTULINUM NEUROTOXIN E CATALYTIC DOMAIN
Descriptor:botulinum neurotoxin type E, ZINC ION, CHLORIDE ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-05-04
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
1ZL5
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CRYSTAL STRUCTURE OF GLU335GLN MUTANT OF CLOSTRIDIUM BOTULINUM NEUROTOXIN E CATALYTIC DOMAIN
Descriptor:botulinum neurotoxin type E, CHLORIDE ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-05-05
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
1ZL6
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CRYSTAL STRUCTURE OF TYR350ALA MUTANT OF CLOSTRIDIUM BOTULINUM NEUROTOXIN E CATALYTIC DOMAIN
Descriptor:botulinum neurotoxin type E, ZINC ION, SULFATE ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-05-05
Release date:2005-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
1ZN3
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CRYSTAL STRUCTURE OF GLU335ALA MUTANT OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE E
Descriptor:botulinum neurotoxin type E, ZINC ION, CHLORIDE ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-05-11
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
Biochemistry, 44, 2005
2A8A
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CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN SEROTYPE F LIGHT CHAIN
Descriptor:Botulinum neurotoxin type F, ZINC ION, CADMIUM ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-07-07
Release date:2005-09-20
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design
Biochemistry, 44, 2005
2A97
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF CLOSTRIDIUM BOTULINUM NEUROTOXIN SEROTYPE F
Descriptor:Botulinum neurotoxin type F, ZINC ION, CADMIUM ION
Authors:Agarwal, R., Binz, T., Swaminathan, S.
Deposit date:2005-07-11
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design
Biochemistry, 44, 2005
2NM1
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STRUCTURE OF BONT/B IN COMPLEX WITH ITS PROTEIN RECEPTOR
Descriptor:Botulinum neurotoxin type B, Synaptotagmin-2
Authors:Jin, R., Rummel, A., Binz, T., Brunger, A.T.
Deposit date:2006-10-20
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Nature, 444, 2006
2QN0
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STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE C1 LIGHT CHAIN PROTEASE
Descriptor:Neurotoxin, ZINC ION
Authors:Jin, R., Sikorra, S., Stegmann, C.M., Pich, A., Binz, T., Brunger, A.T.
Deposit date:2007-07-17
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Biochemistry, 46, 2007
3OBR
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE D BINDING DOMAIN
Descriptor:Botulinum neurotoxin type D, GLYCEROL
Authors:Zong, Y., Lee, K.K., Jin, R.
Deposit date:2010-08-09
Release date:2010-09-08
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem.J., 431, 2010
3OBT
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE D LIGAND BINDING DOMAIN IN COMPLEX WITH N-ACETYLNEURAMINIC ACID
Descriptor:Botulinum neurotoxin type D, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, GLYCEROL
Authors:Lee, K.K., Zong, Y., Jin, R.
Deposit date:2010-08-09
Release date:2010-09-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem.J., 431, 2010
5NCH
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GRIE APO FORM
Descriptor:Leucine hydroxylase
Authors:Lukat, P., Blankenfeldt, W., Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.819 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
5NCI
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GRIE IN COMPLEX WITH COBALT, ALPHA-KETOGLUTARATE AND L-LEUCINE
Descriptor:Leucine hydroxylase, COBALT (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Lukat, P., Blankenfeldt, W., Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
5NCJ
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GRIE IN COMPLEX WITH MANGANESE, SUCCINATE AND (2S,4R)-5-HYDROXYLEUCINE
Descriptor:Leucine hydroxylase, MANGANESE (II) ION, SUCCINIC ACID, ...
Authors:Lukat, P., Blankenfeldt, W., Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
6BVD
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STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE HA LIGHT CHAIN
Descriptor:Light Chain, CALCIUM ION, ACETATE ION, ...
Authors:Jin, R., Lam, K.
Deposit date:2017-12-12
Release date:2018-05-09
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.
Pathog Dis, 76, 2018