3OBT

Crystal structure of Botulinum neurotoxin serotype D ligand binding domain in complex with N-Acetylneuraminic acid

Summary for 3OBT

• Entry DOI: 10.2210/pdb3obt/pdb
• Related: 3OBR
• Descriptor: Botulinum neurotoxin type D, N-acetyl-beta-neuraminic acid, GLYCEROL, ... (4 entities in total)
• Functional Keywords: neurotoxin, gangalioside, hydrolase
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin D light chain: Secreted. Botulinum neurotoxin D heavy chain: Secreted: P19321
• Total number of polymer chains: 1
• Total formula weight: 51642.96

Authors

Lee, K.K.,Zong, Y.,Jin, R. (deposition date: 2010-08-09, release date: 2010-09-08, Last modification date: 2020-07-29)

• Primary citation: Strotmeier, J.,Lee, K.,Volker, A.K.,Mahrhold, S.,Zong, Y.,Zeiser, J.,Zhou, J.,Pich, A.,Bigalke, H.,Binz, T.,Rummel, A.,Jin, R.; Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.; Biochem.J., 431:207-216, 2010; PubMed: 20704566; DOI: 10.1042/BJ20101042

Experimental method

X-RAY DIFFRACTION (2 Å)