5NCI

GriE in complex with cobalt, alpha-ketoglutarate and l-leucine

Summary for 5NCI

Entry DOI	10.2210/pdb5nci/pdb
Descriptor	Leucine hydroxylase, COBALT (II) ION, 2-OXOGLUTARIC ACID, ... (6 entities in total)
Functional Keywords	fe(ii)/alpha-ketoglutarate dependent dioxygenase, hydroxylase, non-heme iron protein, leucine hydroxylase, 5-hydroxyleucine, (2s4r)-5-hydroxyleucine, 4-methyl-proline, griselimycin, methyl-griselimycin, oxidoreductase
Biological source	Streptomyces sp. DSM 40835
Total number of polymer chains	2
Total formula weight	60424.38
Authors	Lukat, P.,Blankenfeldt, W.,Mueller, R. (deposition date: 2017-03-05, release date: 2017-10-04, Last modification date: 2024-01-17)
Primary citation	Lukat, P.,Katsuyama, Y.,Wenzel, S.,Binz, T.,Konig, C.,Blankenfeldt, W.,Bronstrup, M.,Muller, R. Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chem Sci, 8:7521-7527, 2017 Cited by PubMed: 29163906 DOI: 10.1039/c7sc02622f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.755 Å)

Structure validation