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1DNC
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HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON
Descriptor:GLUTATHIONE REDUCTASE, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Becker, K., Savvides, S.N., Keese, M., Schirmer, R.H., Karplus, P.A.
Deposit date:1998-02-20
Release date:1998-05-27
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
1GSN
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HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE
Descriptor:GLUTATHIONE REDUCTASE, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Becker, K., Savvides, S.N., Keese, M., Schirmer, R.H., Karplus, P.A.
Deposit date:1998-02-21
Release date:1998-05-27
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat.Struct.Biol., 5, 1998
1OKT
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X-RAY STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM THE MALARIAL PARASITE PLASMODIUM FALCIPARUM
Descriptor:GLUTATHIONE S-TRANSFERASE, FORMIC ACID
Authors:Fritz-Wolf, K., Becker, A., Rahlfs, s., Harwaldt, P., Schirmer, R.H., Kabsch, W., Becker, K.
Deposit date:2003-07-29
Release date:2003-11-20
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium Falciparum
Proc.Natl.Acad.Sci.USA, 100, 2003
2AAQ
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CRYSTAL STRUCTURE ANALYSIS OF THE HUMAN GLUTAHIONE REDUCTASE, COMPLEXED WITH GOPI
Descriptor:glutathione reductase, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Urig, S., Fritz-Wolf, K., Reau, R., Herold-Mende, C., Toth, K., Davioud-Charvet, E., Becker, K.
Deposit date:2005-07-14
Release date:2006-04-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases.
Angew.Chem.Int.Ed.Engl., 45, 2006
3R3J
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KINETIC AND STRUCTURAL CHARACTERIZATION OF PLASMODIUM FALCIPARUM GLUTAMATE DEHYDROGENASE 2
Descriptor:Glutamate dehydrogenase
Authors:Zocher, K., Fritz-Wolf, K., Kehr, S., Rahlfs, S., Becker, K.
Deposit date:2011-03-16
Release date:2012-03-07
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2.
Mol.Biochem.Parasitol., 183, 2012
6FQX
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PLASMODIUM FALCIPARUM 6-PHOSPHOGLUCONATE DEHYDROGENASE IN ITS APO FORM, IN COMPLEX WITH ITS COFACTOR NADP+ AND IN COMPLEX WITH ITS SUBSTRATE 6-PHOSPHOGLUCONATE
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, GLYCEROL, ...
Authors:Fritz-Wolf, K., Haeussler, K., Reichmann, M., Rahlfs, S., Becker, K.
Deposit date:2018-02-15
Release date:2018-08-22
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
6FQY
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PLASMODIUM FALCIPARUM 6-PHOSPHOGLUCONATE DEHYDROGENASE IN ITS APO FORM, IN COMPLEX WITH ITS COFACTOR NADP+ AND IN COMPLEX WITH ITS SUBSTRATE 6-PHOSPHOGLUCONATE
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Fritz-Wolf, K., Haeussler, K., Reichmann, M., Rahlfs, S., Becker, K.
Deposit date:2018-02-15
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
6FQZ
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PLASMODIUM FALCIPARUM 6-PHOSPHOGLUCONATE DEHYDROGENASE IN ITS APO FORM, IN COMPLEX WITH ITS COFACTOR NADP+ AND IN COMPLEX WITH ITS SUBSTRATE 6-PHOSPHOGLUCONATE
Descriptor:6-phosphogluconate dehydrogenase, decarboxylating, 6-PHOSPHOGLUCONIC ACID, ...
Authors:Fritz-Wolf, K., Haeussler, K., Reichmann, M., Rahlfs, S., Becker, K.
Deposit date:2018-02-15
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.
J. Mol. Biol., 430, 2018
1SNY
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CARBONYL REDUCTASE SNIFFER OF D. MELANOGASTER
Descriptor:sniffer CG10964-PA, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sgraja, T., Ulschmid, J., Becker, K., Schneuwly, S., Klebe, G., Reuter, K., Heine, A.
Deposit date:2004-03-12
Release date:2004-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Insights into the Neuroprotective-acting Carbonyl Reductase Sniffer of Drosophila melanogaster.
J.Mol.Biol., 342, 2004
2AAW
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STUDIES ON LIGAND BINDING AND ENZYME INHIBITION OF PLASMODIUM FALCIPARUM GLUTATHIONE S-TRANSFERASE
Descriptor:glutathione s-transferase, S-HEXYLGLUTATHIONE, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ...
Authors:Hiller, N., Fritz-Wolf, K., Deponte, M., Wende, W., Zimmermann, H., Becker, K.
Deposit date:2005-07-14
Release date:2006-01-10
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition.
Protein Sci., 15, 2006
2J3N
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X-RAY STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1
Descriptor:THIOREDOXIN REDUCTASE 1, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Fritz-Wolf, K., Urig, S., Becker, K.
Deposit date:2006-08-22
Release date:2007-07-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of Human Thioredoxin Reductase 1 Provides Insights Into C-Terminal Rearrangements During Catalysis.
J.Mol.Biol., 370, 2007
3LG0
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STRUCTURE OF PLASMODIUM FALCIPARUM ORNITHINE DELTA-AMINOTRANSFERASE
Descriptor:Ornithine aminotransferase
Authors:Fritz-Wolf, K., Jortzik, E., Stumpf, M., Becker, K.
Deposit date:2010-01-19
Release date:2010-08-04
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase.
J.Mol.Biol., 402, 2010
3NTJ
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REDOX REGULATION OF PLASMODIUM FALCIPARUM ORNITHINE DELTA-AMINOTRANSFERASE
Descriptor:Ornithine aminotransferase, SULFATE ION
Authors:Fritz-Wolf, K., Jortzik, E., Stumpf, M., Becker, K.
Deposit date:2010-07-05
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase
J.Mol.Biol., 402, 2010
3QFA
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CRYSTAL STRUCTURE OF THE HUMAN THIOREDOXIN REDUCTASE-THIOREDOXIN COMPLEX
Descriptor:Thioredoxin reductase 1, cytoplasmic, Thioredoxin, ...
Authors:Fritz-Wolf, K., Kehr, S., Stumpf, M., Rahlfs, S., Becker, K.
Deposit date:2011-01-21
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
3QFB
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CRYSTAL STRUCTURE OF THE HUMAN THIOREDOXIN REDUCTASE-THIOREDOXIN COMPLEX
Descriptor:Thioredoxin reductase 1, cytoplasmic, Thioredoxin, ...
Authors:Fritz-Wolf, K., Kehr, S., Stumpf, M., Rahlfs, S., Becker, K.
Deposit date:2011-01-21
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
4J56
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STRUCTURE OF PLASMODIUM FALCIPARUM THIOREDOXIN REDUCTASE-THIOREDOXIN COMPLEX
Descriptor:Thioredoxin reductase 2, Thioredoxin, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fritz-Wolf, K., Jortzik, E., Stumpf, M., Preuss, J., Iozef, R., Rahlfs, S., Becker, K.
Deposit date:2013-02-08
Release date:2013-07-10
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (2.371 Å)
Cite:Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
4J57
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STRUCTURE OF PLASMODIUM FALCIPARUM THIOREDOXIN REDUCTASE-THIOREDOXIN COMPLEX
Descriptor:Thioredoxin reductase 2, Thioredoxin, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Fritz-Wolf, K., Jortzik, E., Stumpf, M., Preuss, J., Iozef, R., Rahlfs, S., Becker, K.
Deposit date:2013-02-08
Release date:2013-07-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
J.Mol.Biol., 425, 2013
5LLT
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PLASMODIUM FALCIPARUM NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE COMPLEXED WITH NAAD
Descriptor:Nicotinate-nucleotide adenylyltransferase, NICOTINIC ACID ADENINE DINUCLEOTIDE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bathke, J., Fritz-Wolf, K., Brandstaedter, C., Rahlfs, S., Becker, K.
Deposit date:2016-07-28
Release date:2016-11-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
5LM3
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PLASMODIUM FALCIPARUM NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE COMPLEXED WITH APC
Descriptor:Nicotinate-nucleotide adenylyltransferase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 1,2-ETHANEDIOL
Authors:Bathke, J., Fritz-Wolf, K., Rahlfs, S., Brandstaether, C., Burkhardt, A., Becker, K.
Deposit date:2016-07-29
Release date:2016-11-30
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
J. Mol. Biol., 428, 2016
1ALG
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SOLUTION STRUCTURE OF AN HGR INHIBITOR, NMR, 10 STRUCTURES
Descriptor:P11
Authors:Schott, M.K., Nordhoff, A., Becker, K., Kalbitzer, H.R., Schirmer, R.H.
Deposit date:1997-06-03
Release date:1997-10-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors.
Eur.J.Biochem., 245, 1997
1K4Q
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HUMAN GLUTATHIONE REDUCTASE INACTIVATED BY PEROXYNITRITE
Descriptor:Glutathione Reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Savvides, S.N., Scheiwein, M., Boehme, C.C., Arteel, G.E., Karplus, P.A., Becker, K., Schirmer, R.H.
Deposit date:2001-10-08
Release date:2002-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite.
J.Biol.Chem., 277, 2002
1ONF
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLUTATHIONE REDUCTASE
Descriptor:Glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Sarma, G.N., Savvides, S.N., Becker, K., Schirmer, M., Schirmer, R.H., Karplus, P.A.
Deposit date:2003-02-27
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Glutathione reductase of the malarial parasite Plasmodium falciparum: Crystal structure and inhibitor development
J.Mol.Biol., 328, 2003
1XIY
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM ANTIOXIDANT PROTEIN (1-CYS PEROXIREDOXIN)
Descriptor:peroxiredoxin
Authors:Sarma, G.N., Fischer, M., Nickel, C., Becker, K., Karplus, P.A.
Deposit date:2004-09-22
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin.
J.Mol.Biol., 346, 2005
1XW9
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DROSOPHILA THIOREDOXIN, OXIDIZED, P21
Descriptor:thioredoxin
Authors:Wahl, M.C., Irmler, A., Hecker, B., Schirmer, R.H., Becker, K.
Deposit date:2004-10-29
Release date:2004-11-16
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster
J.Mol.Biol., 345, 2005
1XWA
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DROSPOHILA THIOREDOXIN, OXIDIZED, P41212
Descriptor:thioredoxin, CADMIUM ION, CHLORIDE ION
Authors:Wahl, M.C., Irmler, A., Hecker, B., Schirmer, R.H., Becker, K.
Deposit date:2004-10-29
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster
J.Mol.Biol., 345, 2005
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