2AAQ

Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI

Summary for 2AAQ

Entry DOI	10.2210/pdb2aaq/pdb
Descriptor	glutathione reductase, PHOSPHATE ION, CHLORIDE ION, ... (9 entities in total)
Functional Keywords	disulfide reductase, homodimer, antioxidative system, glutathione reduction, gold-coordination, protein gold complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
Total number of polymer chains	1
Total formula weight	54138.14
Authors	Urig, S.,Fritz-Wolf, K.,Reau, R.,Herold-Mende, C.,Toth, K.,Davioud-Charvet, E.,Becker, K. (deposition date: 2005-07-14, release date: 2006-04-04, Last modification date: 2017-10-11)
Primary citation	Urig, S.,Fritz-Wolf, K.,Reau, R.,Herold-Mende, C.,Toth, K.,Davioud-Charvet, E.,Becker, K. Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases. Angew.Chem.Int.Ed.Engl., 45:1881-1886, 2006 Cited by PubMed: 16493712 DOI: 10.1002/anie.200502756 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation