3KOV
| Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors | Descriptor: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte-specific enhancer factor 2A | Authors: | Wu, Y, Dey, R, Han, A, Jayathilaka, N, Philips, M, Ye, J, Chen, L. | Deposit date: | 2009-11-14 | Release date: | 2010-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment. J.Mol.Biol., 397, 2010
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7BZ5
| Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of B38, Light chain of B38, ... | Authors: | Wu, Y, Qi, J, Gao, F. | Deposit date: | 2020-04-26 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2. Science, 368, 2020
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5D82
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5D81
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5D83
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4WBE
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4WBP
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7RNN
| Human ASIC1a-Nb.C1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Nanobodies Nb.C1 | Authors: | Wu, Y, Chen, Z, Sigworth, F.J, Canessa, C.M. | Deposit date: | 2021-07-29 | Release date: | 2021-08-11 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure and analysis of nanobody binding to the human ASIC1a ion channel. Elife, 10, 2021
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5KP4
| Crystal Structure of Ketosteroid Isomerase from Pseudomonas putida (pKSI) bound to 19-nortestosterone | Descriptor: | (8~{R},9~{S},10~{R},13~{S},14~{S},17~{S})-13-methyl-17-oxidanyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1~{H}-cyclop enta[a]phenanthren-3-one, Steroid Delta-isomerase | Authors: | Wu, Y, Boxer, S.G. | Deposit date: | 2016-07-01 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.706 Å) | Cite: | A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase. J.Am.Chem.Soc., 138, 2016
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4NHH
| Structure of 2G12 IgG Dimer | Descriptor: | 2G12 IgG dimer heavy chain, 2G12 IgG dimer light chain, Hepatitis B virus receptor binding protein | Authors: | Wu, Y, West Jr, A.P, Kim, H.J, Thornton, M.E, Ward, A.B, Bjorkman, P.J. | Deposit date: | 2013-11-05 | Release date: | 2014-02-26 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12. Cell Rep, 5, 2013
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5NXQ
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5KP3
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5KP1
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3N6M
| Crystal structure of EV71 RdRp in complex with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, NICKEL (II) ION, RNA-dependent RNA polymerase | Authors: | Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. | Deposit date: | 2010-05-26 | Release date: | 2011-06-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
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3NAF
| Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel (BK Channel) | Descriptor: | Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1,Calcium-activated potassium channel subunit alpha-1 | Authors: | Wu, Y, Yang, Y, Ye, S, Jiang, Y. | Deposit date: | 2010-06-01 | Release date: | 2010-06-30 | Last modified: | 2017-06-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature, 466, 2010
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6F5E
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide | Descriptor: | C-Jun-amino-terminal kinase-interacting protein 1, DD_D12_10_47, Mitogen-activated protein kinase 8 | Authors: | Wu, Y, Mittl, P.R, Honegger, A, Batyuk, A, Plueckthun, A. | Deposit date: | 2017-12-01 | Release date: | 2017-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide To be published
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6G8U
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5LW1
| Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide | Descriptor: | ADENOSINE, C-Jun-amino-terminal kinase-interacting protein 1, DD_232_11_D12, ... | Authors: | Wu, Y, Batyuk, A, Mittl, P.R, Honegger, A, Plueckthun, A. | Deposit date: | 2016-09-15 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions. J.Mol.Biol., 430, 2018
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6G8V
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3N6N
| crystal structure of EV71 RdRp in complex with Br-UTP | Descriptor: | 5-bromouridine 5'-(tetrahydrogen triphosphate), NICKEL (II) ION, RNA-dependent RNA polymerase | Authors: | Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. | Deposit date: | 2010-05-26 | Release date: | 2011-06-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
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3N6L
| The crystal structure of RNA-dependent RNA polymerase of EV71 virus | Descriptor: | NICKEL (II) ION, RNA-dependent RNA polymerase | Authors: | Wu, Y, Rao, Z.H. | Deposit date: | 2010-05-26 | Release date: | 2011-06-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010
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1T4G
| ATPase in complex with AMP-PNP | Descriptor: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Wu, Y, He, Y, Moya, I.A, Qian, X, Luo, Y. | Deposit date: | 2004-04-29 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Archaeal Recombinase RadA; A Snapshot of Its Extended Conformation. Mol.Cell, 15, 2004
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1XU4
| ATPASE IN COMPLEX WITH AMP-PNP, MAGNESIUM AND POTASSIUM CO-F | Descriptor: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Wu, Y, Qian, X, He, Y, Moya, I.A, Luo, Y. | Deposit date: | 2004-10-25 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an ATPase-active form of Rad51 homolog from Methanococcus voltae. Insights into potassium dependence J.Biol.Chem., 280, 2005
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1OP1
| Solution NMR structure of domain 1 of receptor associated protein | Descriptor: | Alpha-2-macroglobulin receptor-associated protein precursor | Authors: | Wu, Y, Migliorini, M, Yu, P, Strickland, D.K, Wang, Y.-X. | Deposit date: | 2003-03-04 | Release date: | 2003-08-26 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. J.Biomol.Nmr, 26, 2003
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1OV2
| Ensemble of the solution structures of domain one of receptor associated protein | Descriptor: | Alpha-2-macroglobulin receptor-associated protein precursor | Authors: | Wu, Y, Migliorini, M, Yu, P, Strickland, D.K, Wang, Y.X. | Deposit date: | 2003-03-25 | Release date: | 2004-04-06 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. J.Biomol.Nmr, 26, 2003
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