5LW1
Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide
Summary for 5LW1
Entry DOI | 10.2210/pdb5lw1/pdb |
Related PRD ID | PRD_000557 |
Descriptor | DD_232_11_D12, Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, ... (6 entities in total) |
Functional Keywords | x-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions, transferase, de novo protein |
Biological source | synthetic construct More |
Total number of polymer chains | 10 |
Total formula weight | 243041.45 |
Authors | Wu, Y.,Batyuk, A.,Mittl, P.R.,Honegger, A.,Plueckthun, A. (deposition date: 2016-09-15, release date: 2017-12-13, Last modification date: 2024-01-17) |
Primary citation | Wu, Y.,Honegger, A.,Batyuk, A.,Mittl, P.R.E.,Pluckthun, A. Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions. J.Mol.Biol., 430:2128-2138, 2018 Cited by PubMed: 29126898DOI: 10.1016/j.jmb.2017.10.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
Download full validation report