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5LW1

Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide

Summary for 5LW1
Entry DOI10.2210/pdb5lw1/pdb
Related PRD IDPRD_000557
DescriptorDD_232_11_D12, Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, ... (6 entities in total)
Functional Keywordsx-ray crystallography; designed ankyrin repeat proteins; protein design; protein engineering; rigid domain fusions, transferase, de novo protein
Biological sourcesynthetic construct
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Total number of polymer chains10
Total formula weight243041.45
Authors
Wu, Y.,Batyuk, A.,Mittl, P.R.,Honegger, A.,Plueckthun, A. (deposition date: 2016-09-15, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citationWu, Y.,Honegger, A.,Batyuk, A.,Mittl, P.R.E.,Pluckthun, A.
Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.
J.Mol.Biol., 430:2128-2138, 2018
Cited by
PubMed: 29126898
DOI: 10.1016/j.jmb.2017.10.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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