3KOV
Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors
Summary for 3KOV
Entry DOI | 10.2210/pdb3kov/pdb |
Descriptor | Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3') (3 entities in total) |
Functional Keywords | mads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, acetylation, activator, alternative splicing, apoptosis, developmental protein, differentiation, disease mutation, dna-binding, isopeptide bond, neurogenesis, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q02078 |
Total number of polymer chains | 8 |
Total formula weight | 58389.76 |
Authors | Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L. (deposition date: 2009-11-14, release date: 2010-02-16, Last modification date: 2024-02-21) |
Primary citation | Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L. Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment. J.Mol.Biol., 397:520-533, 2010 Cited by PubMed: 20132824DOI: 10.1016/j.jmb.2010.01.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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