Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors

Summary for 3KOV

DescriptorMyocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3') (3 entities in total)
Functional Keywordsmads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, acetylation, activator, alternative splicing, apoptosis, developmental protein, differentiation, disease mutation, dna-binding, isopeptide bond, neurogenesis, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q02078
Total number of polymer chains8
Total molecular weight58389.76
Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L. (deposition date: 2009-11-14, release date: 2010-02-16, Last modification date: 2018-04-04)
Primary citation
Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L.
Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment.
J.Mol.Biol., 397:520-533, 2010
PubMed: 20132824 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2010.01.067
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28432 1.4% 11.3% 5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-18