3KOV
Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0046983 | molecular_function | protein dimerization activity |
| I | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| I | 0003677 | molecular_function | DNA binding |
| I | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| I | 0046983 | molecular_function | protein dimerization activity |
| J | 0000977 | molecular_function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| J | 0003677 | molecular_function | DNA binding |
| J | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| J | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PROSITE/UniProt
| site_id | PS00350 |
| Number of Residues | 55 |
| Details | MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY |
| Chain | Residue | Details |
| A | ARG3-TYR57 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 216 |
| Details | Domain: {"description":"MADS-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00251","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | DNA binding: {"description":"Mef2-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
