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3KOV

Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors

Functional Information from GO Data
ChainGOidnamespacecontents
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046983molecular_functionprotein dimerization activity
B0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046983molecular_functionprotein dimerization activity
I0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
I0003677molecular_functionDNA binding
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0046983molecular_functionprotein dimerization activity
J0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
J0003677molecular_functionDNA binding
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0046983molecular_functionprotein dimerization activity
Functional Information from PROSITE/UniProt
site_idPS00350
Number of Residues55
DetailsMADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY
ChainResidueDetails
AARG3-TYR57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsDNA_BIND: Mef2-type => ECO:0000255
ChainResidueDetails
AALA58-GLU86
BALA58-GLU86
IALA58-GLU86
JALA58-GLU86

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000250
ChainResidueDetails
ASER59
BSER59
ISER59
JSER59

218853

PDB entries from 2024-04-24

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