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7T2Q
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BU of 7t2q by Molmil
PEGylated Calmodulin-1 (K148U)
Descriptor: CALCIUM ION, Calmodulin-1, MAGNESIUM ION, ...
Authors:Mackay, J.P, Payne, R.J, Patel, K, Dowman, L.J.
Deposit date:2021-12-06
Release date:2022-10-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine.
Nat Commun, 13, 2022
7TO9
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BU of 7to9 by Molmil
BRD3-BD1 in complex with RaPID linear peptide 2xAcK.4xE (diAcK.4xE)
Descriptor: 2xAcK.4xE (diAcK.4xE), Bromodomain-containing protein 3, GLYCEROL
Authors:Mackay, J.P, Low, J.K.K, Patel, K.
Deposit date:2022-01-23
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.
J.Biol.Chem., 299, 2023
7TO7
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BU of 7to7 by Molmil
BRD3-BD1 in complex with RaPID linear peptide 1xAcK.4XE (monoAcK.4xE)
Descriptor: 1xAcK.4xE (monoAcK.4xE), Bromodomain-containing protein 3, GLYCEROL
Authors:Mackay, J.P, Low, J.K.K, Patel, K.
Deposit date:2022-01-23
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.
J.Biol.Chem., 299, 2023
2HI3
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BU of 2hi3 by Molmil
Solution structure of the homeodomain-only protein HOP
Descriptor: Homeodomain-only protein
Authors:Mackay, J.P, Kook, H, Epstein, J.A, Simpson, R.J, Yung, W.W.
Deposit date:2006-06-28
Release date:2007-01-02
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Analysis of the structure and function of the transcriptional coregulator HOP
Biochemistry, 45, 2006
2MPL
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BU of 2mpl by Molmil
Solution structure of the PR domain of FOG-1
Descriptor: Zinc finger protein ZFPM1
Authors:Mackay, J.P, Clifton, M.K, Westman, B.J, Blobel, G.A.
Deposit date:2014-05-26
Release date:2014-10-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins.
Plos One, 9, 2014
2XU7
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BU of 2xu7 by Molmil
Structural basis for RbAp48 binding to FOG-1
Descriptor: HISTONE-BINDING PROTEIN RBBP4, TETRAETHYLENE GLYCOL, ZINC FINGER PROTEIN ZFPM1
Authors:Lejon, S, Thong, S.Y, Murthy, A, Blobel, G.A, Mackay, J.P, Murzina, N.V, Laue, E.D.
Deposit date:2010-10-15
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights Into Association of the Nurd Complex with Fog-1 from the Crystal Structure of an Rbap48-Fog- 1 Complex.
J.Biol.Chem., 286, 2011
8DNQ
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BU of 8dnq by Molmil
BRD2-BD1 in complex with cyclic peptide 2.2B
Descriptor: Bromodomain-containing protein 2, Cyclic peptide 2.2B, GLYCEROL
Authors:Patel, K, Franck, C, Mackay, J.P.
Deposit date:2022-07-11
Release date:2023-07-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
7JX7
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BU of 7jx7 by Molmil
BRD2-BD2 in complex with a diacetylated-H2A.Z peptide
Descriptor: Bromodomain-containing protein 2, Diacetylated-H2A.Z peptide
Authors:Patel, K, Low, J.K.K, Mackay, J.P, Solomon, P.D.
Deposit date:2020-08-26
Release date:2020-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The bromodomains of BET family proteins can recognize diacetylated histone H2A.Z.
Protein Sci., 30, 2021
6BGH
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BU of 6bgh by Molmil
Solution NMR structure of Brd3 ET domain bound to Brg1 peptide
Descriptor: Brd3_ET, Bromodomain-containing protein 3
Authors:Szyszka, T.N, Wai, D.C, Mackay, J.P.
Deposit date:2017-10-28
Release date:2018-03-21
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
J.Biol.Chem., 293, 2018
6PTL
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BU of 6ptl by Molmil
Structure of the self-association domain of the chromatin looping factor LDB1
Descriptor: LIM domain-binding protein 1
Authors:Macindoe, I, Silva, A, Guss, J.M, Mackay, J.P, Matthews, J.M.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the self-association domain of the chromatin looping factor LDB1
To Be Published
2KAE
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BU of 2kae by Molmil
data-driven model of MED1:DNA complex
Descriptor: 5'-D(*DCP*DGP*DGP*DAP*DAP*DAP*DAP*DGP*DTP*DAP*DTP*DAP*DCP*DTP*DTP*DTP*DTP*DCP*DCP*DG)-3', GATA-type transcription factor, ZINC ION
Authors:Lowry, J.A, Gamsjaeger, R, Thong, S, Hung, W, Kwan, A.H, Broitman-Maduro, G, Matthews, J.M, Maduro, M, Mackay, J.P.
Deposit date:2008-11-04
Release date:2009-01-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural Analysis of MED-1 Reveals Unexpected Diversity in the Mechanism of DNA Recognition by GATA-type Zinc Finger Domains.
J.Biol.Chem., 284, 2009
2KZH
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BU of 2kzh by Molmil
Three-dimensional structure of a truncated phosphoribosylanthranilate isomerase (residues 255-384) from Escherichia coli
Descriptor: Tryptophan biosynthesis protein trpCF
Authors:Setiyaputra, S, Mackay, J.P, Patrick, W.M.
Deposit date:2010-06-17
Release date:2011-03-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Structure of a Truncated Phosphoribosylanthranilate Isomerase Suggests a Unified Model for Evolution of the (beta alpha)8 Barrel Fold
J.Mol.Biol., 408, 2011
2L6Z
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BU of 2l6z by Molmil
haddock model of GATA1NF:Lmo2LIM2-Ldb1LID with FOG
Descriptor: Erythroid transcription factor, LIM domain only 2, linker, ...
Authors:Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M.
Deposit date:2010-12-01
Release date:2011-08-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Proc.Natl.Acad.Sci.USA, 108, 2011
2LFN
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BU of 2lfn by Molmil
Identification of the key regions that drive functional amyloid formation by the fungal hydrophobin EAS
Descriptor: Hydrophobin
Authors:Macindoe, I, Kwan, A.H, Morris, V.K, Mackay, J.P, Sunde, M.
Deposit date:2011-07-06
Release date:2012-01-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS
Proc.Natl.Acad.Sci.USA, 109, 2012
8D4Y
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BU of 8d4y by Molmil
C-terminal SANT-SLIDE domain of human Chromodomain-helicase-DNA-binding protein 4 (CHD4)
Descriptor: Chromodomain-helicase-DNA-binding protein 4
Authors:Moghaddas Sani, H, Deshpande, C.N, Panjikar, S, Patel, K, Mackay, J.P.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.
Nat Commun, 13, 2022
8CV5
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BU of 8cv5 by Molmil
Peptide 4.2B in complex with BRD3.2
Descriptor: ACETYL GROUP, AMINO GROUP, Bromodomain-containing protein 3, ...
Authors:Franck, C, Mackay, J.P.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
8CV7
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BU of 8cv7 by Molmil
Peptide 2.2E in complex with BRD2-BD2
Descriptor: ACETYL GROUP, AMINO GROUP, Isoform 3 of Bromodomain-containing protein 2, ...
Authors:Franck, C, Mackay, J.P.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
8CV6
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BU of 8cv6 by Molmil
Peptide 4.2B in complex with BRD4.2
Descriptor: ACETYL GROUP, AMINO GROUP, BRD4 protein, ...
Authors:Franck, C, Mackay, J.P.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
8CV4
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BU of 8cv4 by Molmil
Peptide 4.2C in complex with BRD4.2
Descriptor: ACETYL GROUP, AMINO GROUP, BRD4 protein, ...
Authors:Franck, C, Mackay, J.P.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
3G9Y
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BU of 3g9y by Molmil
Crystal structure of the second zinc finger from ZRANB2/ZNF265 bound to 6 nt ssRNA sequence AGGUAA
Descriptor: RNA (5'-R(*AP*GP*GP*UP*AP*A)-3'), ZINC ION, Zinc finger Ran-binding domain-containing protein 2
Authors:Loughlin, F.E, McGrath, A.P, Lee, M, Guss, J.M, Mackay, J.P.
Deposit date:2009-02-15
Release date:2009-03-03
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences
Proc.Natl.Acad.Sci.USA, 106, 2009
7UQT
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BU of 7uqt by Molmil
Solution NMR structure of hexahistidine tagged QseM (6H-QseM)
Descriptor: Quorum sensing master protein
Authors:Hall, D.A, Solomon, P.D, Bond, C.S, Ramsay, J.P, Mackay, J.P.
Deposit date:2022-04-20
Release date:2023-03-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria.
Nucleic Acids Res., 51, 2023
3OVU
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BU of 3ovu by Molmil
Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus
Descriptor: Alpha-hemoglobin-stabilizing protein, Hemoglobin subunit alpha, Iron-regulated surface determinant protein H, ...
Authors:Jacques, D.A, Krishna Kumar, K, Caradoc-Davies, T.T, Langley, D.B, Mackay, J.P, Guss, J.M, Gell, D.A.
Deposit date:2010-09-17
Release date:2011-09-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:A new haem pocket structure in alpha-haemoglobin
To be Published
6OM5
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BU of 6om5 by Molmil
Structure of a haemophore from Haemophilus haemolyticus
Descriptor: CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Torrado, M, Walshe, J.L, Mackay, J.P, Guss, J.M, Gell, D.A.
Deposit date:2019-04-18
Release date:2019-12-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.
Mol.Microbiol., 113, 2020
7L4Z
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BU of 7l4z by Molmil
Structure of SARS-CoV-2 spike RBD in complex with cyclic peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-DTY-LYS-ALA-GLY-VAL-VAL-TYR-GLY-TYR-ASN-ALA-TRP-ILE-ARG-CYS-NH2, Spike protein S1
Authors:Christie, M, Mackay, J.P, Passioura, T, Payne, R.J.
Deposit date:2020-12-21
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.
Acs Cent.Sci., 7, 2021
6BGG
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BU of 6bgg by Molmil
Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide
Descriptor: Bromodomain-containing protein 3, CHD4
Authors:Wai, D.C.C, Szyszka, T.N, Campbell, A.E, Kwong, C, Wilkinson-White, L, Silva, A.P.G, Low, J.K.K, Kwan, A.H, Gamsjaeger, R, Lu, B, Vakoc, C.R, Blobel, G.A, Mackay, J.P.
Deposit date:2017-10-28
Release date:2018-03-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
J. Biol. Chem., 293, 2018

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PDB entries from 2024-09-18

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