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4NHM
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CRYSTAL STRUCTURE OF TPA1P FROM SACCHAROMYCES CEREVISIAE, TERMINATION AND POLYADENYLATION PROTEIN 1, IN COMPLEX WITH N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:PKHD-type hydroxylase TPA1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, MANGANESE (II) ION, ...
Authors:Scotti, J.S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHX
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CRYSTAL STRUCTURE OF HUMAN OGFOD1, 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN CONTAINING 1, IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, SODIUM ION, ...
Authors:Horita, S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHY
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CRYSTAL STRUCTURE OF HUMAN OGFOD1, 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN CONTAINING 1, IN COMPLEX WITH PYRIDINE-2,4-DICARBOXYLIC ACID (2,4-PDCA)
Descriptor:2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, GLYCEROL, ...
Authors:Horita, S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
2W0X
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FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, FE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2008-10-10
Release date:2009-11-24
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2WA3
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FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-HYDROXYPHENYL)-2-OXOACETIC ACID
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2009-02-02
Release date:2010-04-21
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2WA4
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FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, N,3-DIHYDROXYBENZAMIDE, ...
Authors:Conejo-Garcia, A., Lienard, B.M.R., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2009-02-02
Release date:2010-04-21
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Bioorg. Med. Chem. Lett., 20, 2010
2WWU
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PHD FINGER PROTEIN 8
Descriptor:PHD FINGER PROTEIN 8, SULFATE ION, ACETATE ION, ...
Authors:Yue, W.W., Hozjan, V., Cooper, C., Tumber, A., Krojer, T., Muniz, J., Allerston, C., Salah, E., McDonough, M.A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Schofield, C.J., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-29
Release date:2009-11-17
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
FEBS Lett., 584, 2010
2XDV
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF FLJ14393
Descriptor:MYC-INDUCED NUCLEAR ANTIGEN, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Krojer, T., Muniz, J.R.C., Ng, S.S., Pilka, E., Guo, K., Pike, A.C.W., Filippakopoulos, P., Knapp, S., Kavanagh, K.L., Gileadi, O., Bunkoczi, G., Yue, W.W., Niesen, F., Sobott, F., Fedorov, O., Savitsky, P., Kochan, G., Daniel, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
2XUM
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FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER)
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, ASP-SUBSTRATE PEPTIDE 2, ZINC ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2010-10-19
Release date:2010-12-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
J. Biol. Chem., 286, 2011
2Y0I
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, TANKYRASE-2, FE (II) ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2010-12-02
Release date:2011-02-02
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
FEBS J., 278, 2011
3U4S
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HISTONE LYSINE DEMETHYLASE JMJD2A IN COMPLEX WITH T11C PEPTIDE SUBSTRATE CROSSLINKED TO N-OXALYL-D-CYSTEINE
Descriptor:Lysine-specific demethylase 4A, HISTONE 3 TAIL ANALOG (T11C Peptide), NICKEL (II) ION, ...
Authors:Ma, J., McDonough, M.A., Schofield, C.J.
Deposit date:2011-10-10
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Angew.Chem.Int.Ed.Engl., 51, 2012
4CCL
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X-RAY STRUCTURE OF E. COLI YCFD
Descriptor:50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION
Authors:McDonough, M.A., Ho, C.H., Kershaw, N.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-04-30
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CQH
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STRUCTURE OF INFRARED FLUORESCENT PROTEIN IFP2.0
Descriptor:BACTERIOPHYTOCHROME, 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium-2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, SODIUM ION
Authors:Lafaye, C., Yu, D., Noirclerc-Savoye, M., Shu, X., Royant, A.
Deposit date:2014-02-17
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:An Improved Monomeric Infrared Fluorescent Protein for Neuronal and Tumour Brain Imaging.
Nat.Commun., 5, 2014
4CSW
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE
Descriptor:CUPIN 4 FAMILY PROTEIN, CITRIC ACID, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-11
Release date:2014-04-09
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CUG
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE IN COMPLEX SUBSTRATE FRAGMENT
Descriptor:CUPIN 4 FAMILY PROTEIN, 50S RIBOSOMAL PROTEIN L16, MANGANESE (II) ION, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-18
Release date:2014-04-16
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4LIT
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STRUCTURE OF YCFD A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND 2-OXOGLUTARATE.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, 2-OXOGLUTARIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIU
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, TRIS(HYDROXYETHYL)AMINOMETHANE, PHOSPHATE ION
Authors:Brissett, N.C., Doherty, A.J., Fox, G.C.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIV
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND SUCCINIC ACID.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, SUCCINIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
5FWE
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JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3ME2S PEPTIDE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, SYNTHETIC PEPTIDE, NICKEL (II) ION, ...
Authors:Chowdhury, R., Walport, L.J., Schofield, C.J.
Deposit date:2016-02-15
Release date:2016-04-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Arginine Demethylation is Catalysed by a Subset of Jmjc Histone Lysine Demethylases.
Nat.Commun., 7, 2016
5L9B
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9R
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9V
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-11
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.829 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LA9
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/V314C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-2)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAS
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C/R396T) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-3)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAT
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) P317R VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-15
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016