6RY9
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6S2D
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6RYQ
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6RZC
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8C65
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7ABK
| Helical structure of PspA | Descriptor: | Chloroplast membrane-associated 30 kD protein | Authors: | Junglas, B, Huber, S.T, Mann, D, Heidler, T, Clarke, M, Schneider, D, Sachse, C. | Deposit date: | 2020-09-07 | Release date: | 2021-08-04 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Cell, 184, 2021
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6EHM
| Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles | Descriptor: | Membrane-associated protein VP24, Nucleoprotein | Authors: | Wan, W, Kolesnikova, L, Clarke, M, Koehler, A, Noda, T, Becker, S, Briggs, J.A.G. | Deposit date: | 2017-09-13 | Release date: | 2017-11-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | Structure and assembly of the Ebola virus nucleocapsid. Nature, 551, 2017
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6EHL
| Model of the Ebola virus nucleoprotein in recombinant nucleocapsid-like assemblies | Descriptor: | Nucleoprotein | Authors: | Wan, W, Kolesnikova, L, Clarke, M, Koehler, A, Noda, T, Becker, S, Briggs, J.A.G. | Deposit date: | 2017-09-13 | Release date: | 2017-11-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structure and assembly of the Ebola virus nucleocapsid. Nature, 551, 2017
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1DYL
| 9 ANGSTROM RESOLUTION CRYO-EM RECONSTRUCTION STRUCTURE OF SEMLIKI FOREST VIRUS (SFV) AND FITTING OF THE CAPSID PROTEIN STRUCTURE IN THE EM DENSITY | Descriptor: | NUCLEOCAPSID PROTEIN | Authors: | Mancini, E.J, Clarke, M, Gowen, B.E, Rutten, T, Fuller, S.D. | Deposit date: | 2000-02-02 | Release date: | 2000-08-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Cryo-Electron Microscopy Reveals the Functional Organization of an Enveloped Virus, Semliki Forest Virus. Mol.Cell, 5, 2000
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8CYH
| Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, A12 antibody heavy chain, A12 antibody light chain, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-23 | Release date: | 2023-06-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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8CXC
| Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | 3F2 Antibody heavy chain, 3F2 Antibody light chain, Mesothelin, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-20 | Release date: | 2023-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.31 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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8CZ8
| Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics | Descriptor: | Mesothelin, cleaved form, SULFATE ION, ... | Authors: | Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E. | Deposit date: | 2022-05-24 | Release date: | 2023-06-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3, 2023
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7ZF1
| Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA | Descriptor: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | Authors: | Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H. | Deposit date: | 2022-03-31 | Release date: | 2022-11-16 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. Embo J., 42, 2023
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6RZ1
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2N2H
| Solution structure of Sds3 in complex with Sin3A | Descriptor: | Paired amphipathic helix protein Sin3a, Sin3 histone deacetylase corepressor complex component SDS3 | Authors: | Clark, M, Radhakrishnan, I. | Deposit date: | 2015-05-08 | Release date: | 2015-07-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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7AW0
| MerTK kinase domain in complex with purine inhibitor | Descriptor: | 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine, Tyrosine-protein kinase Mer | Authors: | Schimpl, M, Nissink, J.W.M, Blackett, C, Clarke, M, Disch, J, Goldberg, K, Guilinger, J, Hennessy, E.J, Jetson, R, Ginkunja, D, Hardaker, E, Keefe, A, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S, Zhang, Y. | Deposit date: | 2020-11-06 | Release date: | 2021-03-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021
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7SJQ
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5OTE
| MRCK beta in complex with BDP-00008900 | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(6~{S})-1,8-diazaspiro[5.5]undecan-8-yl]-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-1,3-thiazole, CHLORIDE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2017-08-21 | Release date: | 2018-02-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res., 78, 2018
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5OTF
| MRCK beta in complex with BDP-00009066 | Descriptor: | (6~{S})-8-(3-pyrimidin-4-yl-1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,8-diazaspiro[5.5]undecane, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Schuettelkopf, A.W. | Deposit date: | 2017-08-21 | Release date: | 2018-02-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res., 78, 2018
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7SND
| Pacifastin related protease inhibitors | Descriptor: | GLYCEROL, PHOSPHATE ION, Pacifastin-related peptide | Authors: | Gewe, M.M, Strong, R.K. | Deposit date: | 2021-10-27 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager. Sci Transl Med, 14, 2022
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7SNC
| Pacifastin related protease inhibitors | Descriptor: | Protease inhibitor | Authors: | Gewe, M.M, Strong, R.K. | Deposit date: | 2021-10-27 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager. Sci Transl Med, 14, 2022
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7JZJ
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7JZT
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2XFC
| CHIKUNGUNYA E1 E2 ENVELOPE GLYCOPROTEINS FITTED IN SEMLIKI FOREST VIRUS cryo-EM MAP | Descriptor: | E1 ENVELOPE GLYCOPROTEIN, E2 ENVELOPE GLYCOPROTEIN | Authors: | Voss, J.E, Vaney, M.C, Duquerroy, S, Rey, F.A. | Deposit date: | 2010-05-21 | Release date: | 2010-11-24 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Glycoprotein Organization of Chikungunya Virus Particles Revealed by X-Ray Crystallography Nature, 468, 2010
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6RSF
| NMR structure of pleurocidin KR in SDS micelles | Descriptor: | Pleurocidin | Authors: | Manzo, G, Mason, A.J. | Deposit date: | 2019-05-21 | Release date: | 2020-12-09 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy. Commun Biol, 3, 2020
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