8CXC

Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics

Summary for 8CXC

• Entry DOI: 10.2210/pdb8cxc/pdb
• Related: 4f3f
• Descriptor: 3F2 Antibody light chain, 3F2 Antibody heavy chain, Mesothelin, cleaved form, ... (4 entities in total)
• Functional Keywords: antibody, complex, tumor associated antigen, antitumor protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 108466.43

Authors

Bandaranayake, A.D.,Rupert, P.B.,Lin, I.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Carter, J.,Meshinchi, S.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. (deposition date: 2022-05-20, release date: 2023-06-07, Last modification date: 2024-10-30)

• Primary citation: Lin, I.,Rupert, P.B.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Hoffstrom, B.G.,Carter, J.,Meshinchi, S.,Bandaranayake, A.D.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E.; Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics; Front. Drug Discov., 3:-, 2023; DOI: 10.3389/fddsv.2023.1216516

Experimental method

X-RAY DIFFRACTION (4.31 Å)