8CXC
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | 3F2 Antibody light chain | polymer | 213 | 23391.6 | 1 | Mus musculus (Mouse) | ||
| 2 | B (H) | 3F2 Antibody heavy chain | polymer | 218 | 23018.8 | 1 | Mus musculus (Mouse) | ||
| 3 | C (M) | Mesothelin, cleaved form | polymer | 327 | 36963.2 | 1 | UniProt (Q13421) Pfam (PF06060) | Homo sapiens (human) | |
| 4 | D (A) | scFv Amatuximab | polymer | 234 | 25092.8 | 1 | Mus musculus (Mouse) |
Sequence modifications
M: 296 - 605 (UniProt: Q13421)
| PDB | External Database | Details |
|---|---|---|
| Gly 606 | - | expression tag |
| Ser 607 | - | expression tag |
| Gly 608 | - | expression tag |
| Leu 609 | - | expression tag |
| Asn 610 | - | expression tag |
| Asp 611 | - | expression tag |
| Ile 612 | - | expression tag |
| Phe 613 | - | expression tag |
| Glu 614 | - | expression tag |
| Ala 615 | - | expression tag |
| Gln 616 | - | expression tag |
| Lys 617 | - | expression tag |
| Ile 618 | - | expression tag |
| Glu 619 | - | expression tag |
| Trp 620 | - | expression tag |
| His 621 | - | expression tag |
| Glu 622 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 108466.4 | |
| All* | Total formula weight | 108466.4 |
