8CYH

Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics

Summary for 8CYH

Entry DOI	10.2210/pdb8cyh/pdb
Descriptor	A12 antibody light chain, A12 antibody heavy chain, Mesothelin, cleaved form, ... (4 entities in total)
Functional Keywords	antibody, complex, tumor associated antigen, antitumor protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	84039.52
Authors	Bandaranayake, A.D.,Rupert, P.B.,Lin, I.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Carter, J.,Meshinchi, S.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. (deposition date: 2022-05-23, release date: 2023-06-07, Last modification date: 2023-12-20)
Primary citation	Lin, I.,Rupert, P.B.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Hoffstrom, B.G.,Carter, J.,Meshinchi, S.,Bandaranayake, A.D.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics Front. Drug Discov., 3:-, 2023 Cited by DOI: 10.3389/fddsv.2023.1216516 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.38 Å)

Structure validation