8CYH
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L | A12 antibody light chain | polymer | 214 | 23325.7 | 1 | Homo sapiens (Human) | ||
2 | H | A12 antibody heavy chain | polymer | 222 | 23308.2 | 1 | Homo sapiens (Human) | ||
3 | M | Mesothelin, cleaved form | polymer | 327 | 36963.2 | 1 | UniProt (Q13421) Pfam (PF06060) In PDB | Homo sapiens (human) | |
4 | M | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
M: 296 - 605 (UniProt: Q13421)
PDB | External Database | Details |
---|---|---|
Gly 606 | - | expression tag |
Ser 607 | - | expression tag |
Gly 608 | - | expression tag |
Leu 609 | - | expression tag |
Asn 610 | - | expression tag |
Asp 611 | - | expression tag |
Ile 612 | - | expression tag |
Phe 613 | - | expression tag |
Glu 614 | - | expression tag |
Ala 615 | - | expression tag |
Gln 616 | - | expression tag |
Lys 617 | - | expression tag |
Ile 618 | - | expression tag |
Glu 619 | - | expression tag |
Trp 620 | - | expression tag |
His 621 | - | expression tag |
Glu 622 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 83597.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 84039.5 |