Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5OTF

MRCK beta in complex with BDP-00009066

Summary for 5OTF
Entry DOI10.2210/pdb5otf/pdb
DescriptorSerine/threonine-protein kinase MRCK beta, CHLORIDE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsmyotonic dystrophy kinase-related cdc42-binding kinase, metastasis, cell invasion, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q9Y5S2
Total number of polymer chains1
Total formula weight48531.40
Authors
Schuettelkopf, A.W. (deposition date: 2017-08-21, release date: 2018-02-21, Last modification date: 2024-01-17)
Primary citationUnbekandt, M.,Belshaw, S.,Bower, J.,Clarke, M.,Cordes, J.,Crighton, D.,Croft, D.R.,Drysdale, M.J.,Garnett, M.J.,Gill, K.,Gray, C.,Greenhalgh, D.A.,Hall, J.A.M.,Konczal, J.,Lilla, S.,McArthur, D.,McConnell, P.,McDonald, L.,McGarry, L.,McKinnon, H.,McMenemy, C.,Mezna, M.,Morrice, N.A.,Munro, J.,Naylor, G.,Rath, N.,Schuttelkopf, A.W.,Sime, M.,Olson, M.F.
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Cancer Res., 78:2096-2114, 2018
Cited by
PubMed: 29382705
DOI: 10.1158/0008-5472.CAN-17-2870
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon