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2V5L
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BU of 2v5l by Molmil
Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: as Observed in a New Crystal Form: Implications for the Reaction Mechanism
Descriptor: SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Zeelen, J.P, Wierenga, R.K.
Deposit date:2007-07-06
Release date:2007-07-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: As Observed in a New Crystal Form: Implications for the Reaction Mechanism
Proteins: Struct.,Funct., Genet., 16, 1993
6TIM
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BU of 6tim by Molmil
THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor: SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1VIN
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BU of 1vin by Molmil
BOVINE CYCLIN A3
Descriptor: CYCLIN A
Authors:Noble, M.E.M, Endicott, J.A.E, Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
8ROZ
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BU of 8roz by Molmil
Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, M-phase inducer phosphatase 1
Authors:Rowland, R.J, Noble, M.E.M, Endicott, J.A.
Deposit date:2024-01-12
Release date:2024-05-29
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of the CDK2-cyclin A-CDC25A complex.
Nat Commun, 15, 2024
1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
8BYL
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BU of 8byl by Molmil
Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex
Descriptor: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ...
Authors:Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M.
Deposit date:2022-12-13
Release date:2023-06-28
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
5LRQ
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BU of 5lrq by Molmil
BRD4 in complex with ERK5 inhibitor XMD8-92
Descriptor: 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4
Authors:Martin, M.P, Noble, M.E.M.
Deposit date:2016-08-19
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.
Eur.J.Med.Chem., 178, 2019
7OZT
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BU of 7ozt by Molmil
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Descriptor: Camelid nanobody NB09, Cyclin-dependent kinase inhibitor 2A
Authors:Pastok, M.W, Burbidge, O, Itzhaki, L, Endicott, J.A, Noble, M.E.M.
Deposit date:2021-06-28
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
To Be Published
1H27
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BU of 1h27 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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BU of 1h25 by Molmil
CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H24
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BU of 1h24 by Molmil
CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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BU of 1h28 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1OW6
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BU of 1ow6 by Molmil
Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase
Descriptor: Focal adhesion kinase 1, Paxillin
Authors:Hoellerer, M.K, Noble, M.E.M, Labesse, G, Campbell, I.D, Werner, J.M, Arold, S.T.
Deposit date:2003-03-28
Release date:2003-10-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular Recognition of Paxillin LD motifs by the Focal Adhesion Targeting Domain
Structure, 11, 2003
6SG4
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BU of 6sg4 by Molmil
Structure of CDK2/cyclin A M246Q, S247EN
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2
Authors:Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A.
Deposit date:2019-08-02
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
J.Mol.Biol., 433, 2021
1H26
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BU of 1h26 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
Descriptor: CELL DIVISION PROTEIN KINASE 2, CELLULAR TUMOR ANTIGEN P53, CYCLIN A2
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
2IW8
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BU of 2iw8 by Molmil
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MONOTHIOGLYCEROL, ...
Authors:Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
Deposit date:2006-06-27
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
2IW9
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BU of 2iw9 by Molmil
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ...
Authors:Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
Deposit date:2006-06-27
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
2IW6
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BU of 2iw6 by Molmil
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ...
Authors:Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
Deposit date:2006-06-26
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
2JCQ
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BU of 2jcq by Molmil
The hyaluronan binding domain of murine CD44 in a Type A complex with an HA 8-mer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD44 ANTIGEN, GLYCEROL
Authors:Banerji, S, Wright, A.J, Noble, M.E.M, Mahoney, D.J, Campbell, I.D, Day, A.J, Jackson, D.G.
Deposit date:2007-01-03
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of the Cd44-Hyaluronan Complex Provide Insight Into a Fundamental Carbohydrate-Protein Interaction.
Nat.Struct.Mol.Biol., 14, 2008
2JCP
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BU of 2jcp by Molmil
The hyaluronan binding domain of murine CD44
Descriptor: CD44 ANTIGEN
Authors:Banerji, S, Wright, A.J, Noble, M.E.M, Mahoney, D.J, Campbell, I.D, Day, A.J, Jackson, D.G.
Deposit date:2007-01-03
Release date:2007-01-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the Cd44-Hyaluronan Complex Provide Insight Into a Fundamental Carbohydrate-Protein Interaction.
Nat.Struct.Mol.Biol., 14, 2008
2JCR
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BU of 2jcr by Molmil
The hyaluronan binding domain of murine CD44 in a Type B complex with an HA 8-mer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD44 ANTIGEN, GLYCEROL
Authors:Banerji, S, Wright, A.J, Noble, M.E.M, Mahoney, D.J, Campbell, I.D, Day, A.J, Jackson, D.G.
Deposit date:2007-01-03
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Cd44-Hyaluronan Complex Provide Insight Into a Fundamental Carbohydrate-Protein Interaction.
Nat.Struct.Mol.Biol., 14, 2008
2BWB
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BU of 2bwb by Molmil
Crystal structure of the UBA domain of Dsk2 from S. cerevisiae
Descriptor: UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWF
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BU of 2bwf by Molmil
Crystal structure of the UBL domain of Dsk2 from S. cerevisiae
Descriptor: FORMIC ACID, UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2C1J
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BU of 2c1j by Molmil
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
Authors:Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
Deposit date:2005-09-15
Release date:2005-11-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2CCH
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BU of 2cch by Molmil
The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006

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