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2JUS
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BU of 2jus by Molmil
alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
Descriptor: Alpha-conotoxin RgIA
Authors:Feng, Z, Ellison, M.
Deposit date:2007-09-02
Release date:2011-05-25
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
J.Mol.Biol., 377, 2008
2JUT
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BU of 2jut by Molmil
alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
Descriptor: Alpha-conotoxin RgIA
Authors:Feng, Z, Ellison, M.
Deposit date:2007-09-02
Release date:2011-05-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
J.Mol.Biol., 377, 2008
2JUR
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BU of 2jur by Molmil
alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
Descriptor: Alpha-conotoxin RgIA
Authors:Feng, Z, Ellison, M.
Deposit date:2007-09-02
Release date:2011-05-25
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
J.Mol.Biol., 377, 2008
2JUQ
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BU of 2juq by Molmil
alpha-RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
Descriptor: Alpha-conotoxin RgIA
Authors:Feng, Z, Ellison, M.
Deposit date:2007-09-02
Release date:2011-05-25
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
J.Mol.Biol., 377, 2008
2XCN
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BU of 2xcn by Molmil
Crystal structure of HCV NS3 protease with a boronate inhibitor
Descriptor: MAGNESIUM ION, N-[(CYCLOPENTYLOXY)CARBONYL]-3-METHYL-L-VALYL-(4R)-N-{(1R)-3-HYDROXY-1-[HYDROXY(OXIDO)BORANYL]PROPYL}-4-(ISOQUINOLIN-1-YLOXY)-L-PROLINAMIDE, NS3 PROTEASE, ...
Authors:Li, X, Zhang, Y.-K, Liu, Y, Ding, C.Z, Li, Q, Zhou, Y, Plattner, J.J, Baker, S.J, Qian, X, Fan, D, Liao, L, Ni, Z.-J, White, G.V, Mordaunt, J.E, Lazarides, L.X, Slater, M.J, Jarvest, R.L, Thommes, P, Ellis, M, Edge, C.M, Hubbard, J.A, Nassau, P, McDowell, B, Skarzynski, T.J, Rowland, P, Somers, D.O, Kazmierski, W.M, Grimes, R.M, Wright, L.L, Smith, G.K, Zou, W, Wright, J, Pennicott, L.E.
Deposit date:2010-04-23
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
2XCF
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BU of 2xcf by Molmil
Crystal structure of HCV NS3 protease with a boronate inhibitor
Descriptor: CYCLOPENTYL N-[(2S)-1-[(2S,4R)-2-[[(4R)-8-HYDROXY-1,6,10-TRIOXA-5$L^{4}-BORASPIRO[4.5]DECAN-4-YL]CARBAMOYL]-4-ISOQUINOLIN-1-YLOXY-PYRROLIDIN-1-YL]-3,3-DIMETHYL-1-OXO-BUTAN-2-YL]CARBAMATE, MAGNESIUM ION, NS3 PROTEASE, ...
Authors:Li, X, Zhang, Y.-K, Liu, Y, Ding, C.Z, Li, Q, Zhou, Y, Plattner, J.J, Baker, S.J, Qian, X, Fan, D, Liao, L, Ni, Z.-J, White, G.V, Mordaunt, J.E, Lazarides, L.X, Slater, M.J, Jarvest, R.L, Thommes, P, Ellis, M, Edge, C.M, Hubbard, J.A, Nassau, P, McDowell, B, Skarzynski, T.J, Rowland, P, Somers, D.O, Kazmierski, W.M, Grimes, R.M, Wright, L.L, Smith, G.K, Zou, W, Wright, J, Pennicott, L.E.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
1ZMY
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BU of 1zmy by Molmil
cAbBCII-10 VHH framework with CDR loops of cAbLys3 grafted on it and in complex with hen egg white lysozyme
Descriptor: Antibody cabbcII-10:lys3, Lysozyme C
Authors:Saerens, D, Pellis, M, Loris, R, Pardon, E, Dumoulin, M, Matagne, A, Wyns, L, Muyldermans, S, Conrath, K.
Deposit date:2005-05-11
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies
J.Mol.Biol., 352, 2005
3G9A
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BU of 3g9a by Molmil
Green fluorescent protein bound to minimizer nanobody
Descriptor: Green fluorescent protein, Minimizer
Authors:Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U.
Deposit date:2009-02-13
Release date:2009-12-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.614 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
3K1K
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BU of 3k1k by Molmil
Green fluorescent protein bound to enhancer nanobody
Descriptor: Enhancer, Green Fluorescent Protein
Authors:Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U.
Deposit date:2009-09-28
Release date:2009-12-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
4YH3
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BU of 4yh3 by Molmil
Crystal structure of human BRD4(1) in complex with 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19a)
Descriptor: 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one, Bromodomain-containing protein 4
Authors:White, A, Lakshminarasimhan, D, Suto, R.K.
Deposit date:2015-02-26
Release date:2016-01-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Bioorg.Med.Chem.Lett., 25, 2015
4YH4
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BU of 4yh4 by Molmil
Crystal structure of human BRD4(1) in complex with 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19d)
Descriptor: 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one, Bromodomain-containing protein 4, GLYCEROL, ...
Authors:Lakshminarasimhan, D, White, A, Suto, R.K.
Deposit date:2015-02-26
Release date:2016-01-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Bioorg.Med.Chem.Lett., 25, 2015
5EJC
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BU of 5ejc by Molmil
Crystal structural of the TSC1-TBC1D7 complex
Descriptor: Hamartin, TBC1 domain family member 7
Authors:Wang, Z, Qin, J, Gong, W, Xu, W.
Deposit date:2015-11-01
Release date:2016-03-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).
J.Biol.Chem., 291, 2016
6SSH
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BU of 6ssh by Molmil
Structure of the TSC2 GAP domain
Descriptor: 1,2-ETHANEDIOL, GTPase activator-like protein
Authors:Hansmann, P, Kiontke, S, Kummel, D.
Deposit date:2019-09-06
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.
Structure, 28, 2020
8UG3
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BU of 8ug3 by Molmil
Crystal structure of KHK-C and compound 23
Descriptor: 2-[(4P)-4-{2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl}-1H-pyrazol-1-yl]-1-(piperazin-1-yl)ethan-1-one, GLYCEROL, Ketohexokinase, ...
Authors:Durbin, J.D, Guo, S.Y.
Deposit date:2023-10-05
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
J.Med.Chem., 66, 2023
8UG1
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BU of 8ug1 by Molmil
Crystal structure of KHK-C and compound 13
Descriptor: GLYCEROL, Ketohexokinase, SULFATE ION, ...
Authors:Durbin, J.D, Guo, S.Y.
Deposit date:2023-10-05
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
J.Med.Chem., 66, 2023
4PVU
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BU of 4pvu by Molmil
Crystal structure of the complex between PPARgamma-LBD and the R enantiomer of Mbx-102 (Metaglidasen)
Descriptor: (2R)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid, Peroxisome proliferator-activated receptor gamma
Authors:Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Piemontese, L, Lavecchia, A.
Deposit date:2014-03-18
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles.
Chemmedchem, 10, 2015
7A0N
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BU of 7a0n by Molmil
Structure of TSC1 NTD and linker domain
Descriptor: Uncharacterized protein,Uncharacterized protein
Authors:Fitzian, K, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
7A0M
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BU of 7a0m by Molmil
TSC1 N-terminal domain
Descriptor: SULFATE ION, TSC1 N-terminal domain
Authors:Zech, R, Kiontke, S, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
4PWL
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BU of 4pwl by Molmil
Crystal structure of the complex between PPARgamma-LBD and the S enantiomer of Mbx-102 (Metaglidasen)
Descriptor: (2S)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid, Peroxisome proliferator-activated receptor gamma
Authors:Pochetti, G, Montanari, R, Capelli, D, Loiodice, F, Laghezza, A, Lavecchia, A, Piemontese, L.
Deposit date:2014-03-20
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles.
Chemmedchem, 10, 2015

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