4YH4

Crystal structure of human BRD4(1) in complex with 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19d)

Summary for 4YH4

Entry DOI	10.2210/pdb4yh4/pdb
Related	4YH3
Descriptor	Bromodomain-containing protein 4, 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one, GLYCEROL, ... (5 entities in total)
Functional Keywords	brd4(1), protein binding
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15774.03
Authors	Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2015-02-26, release date: 2016-01-13, Last modification date: 2024-02-28)
Primary citation	Duffy, B.C.,Liu, S.,Martin, G.S.,Wang, R.,Hsia, M.M.,Zhao, H.,Guo, C.,Ellis, M.,Quinn, J.F.,Kharenko, O.A.,Norek, K.,Gesner, E.M.,Young, P.R.,McLure, K.G.,Wagner, G.S.,Lakshminarasimhan, D.,White, A.,Suto, R.K.,Hansen, H.C.,Kitchen, D.B. Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design. Bioorg.Med.Chem.Lett., 25:2818-2823, 2015 Cited by PubMed: 26022843 DOI: 10.1016/j.bmcl.2015.04.107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation