3CUE
| Crystal structure of a TRAPP subassembly activating the Rab Ypt1p | Descriptor: | GTP-binding protein YPT1, PALMITIC ACID, Transport protein particle 18 kDa subunit, ... | Authors: | Cai, Y, Reinisch, K.M. | Deposit date: | 2008-04-16 | Release date: | 2008-07-08 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell(Cambridge,Mass.), 133, 2008
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4U7N
| Inactive structure of histidine kinase | Descriptor: | Histidine protein kinase sensor protein | Authors: | Cai, Y, Hu, X, Sang, J. | Deposit date: | 2014-07-31 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol, 73, 2017
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4ZKI
| The crystal structure of Histidine Kinase YycG with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase | Authors: | Cai, Y. | Deposit date: | 2015-04-30 | Release date: | 2016-05-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.401 Å) | Cite: | Conformational dynamics of the essential sensor histidine kinase WalK Acta Crystallogr D Struct Biol, 73, 2017
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4TU3
| Crystal structure of yeast Sac1/Vps74 complex | Descriptor: | Phosphoinositide phosphatase SAC1, Vacuolar protein sorting-associated protein 74 | Authors: | Cai, Y, Horenkamp, F.A, Reinisch, K.R. | Deposit date: | 2014-06-23 | Release date: | 2014-08-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.187 Å) | Cite: | Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. J.Cell Biol., 206, 2014
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4U7O
| Active histidine kinase bound with ATP | Descriptor: | AMP PHOSPHORAMIDATE, Histidine protein kinase sensor protein | Authors: | Cai, Y, Hu, X, Sang, J. | Deposit date: | 2014-07-31 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.395 Å) | Cite: | Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol, 73, 2017
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1Q6X
| Crystal structure of rat choline acetyltransferase | Descriptor: | SODIUM ION, choline O-acetyltransferase | Authors: | Cai, Y, Rodgers, D.W. | Deposit date: | 2003-08-14 | Release date: | 2004-06-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders. Embo J., 23, 2004
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5C93
| Histidine kinase with ATP | Descriptor: | Histidine kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION | Authors: | Cai, Y. | Deposit date: | 2015-06-26 | Release date: | 2016-07-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.518 Å) | Cite: | Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol, 73, 2017
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5CVV
| coniferyl alcohol bound monolignol 4-O-methyltransferase 9 | Descriptor: | (Iso)eugenol O-methyltransferase, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Cai, Y, Liu, C.-J. | Deposit date: | 2015-07-27 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure of coniferyl alcohol bound monolignol 4-O-methyltransferase 9 at 1.73 Angstroms resolution To Be Published
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5CVJ
| Monolignol 4-O-methyltransferase 5 - coniferyl alcohol | Descriptor: | (Iso)eugenol O-methyltransferase, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol, NITRATE ION, ... | Authors: | Cai, Y, Liu, C.-J. | Deposit date: | 2015-07-27 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of coniferyl alcohol bound monolignol 4-O-methyltransferase at 1.68 Angstroms resolution To Be Published
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5CVU
| sinpyl alcohol bound monolignol 4-O-methyltransferase 5 | Descriptor: | (Iso)eugenol O-methyltransferase, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenol, NITRATE ION, ... | Authors: | Cai, Y, Liu, C.-J. | Deposit date: | 2015-07-27 | Release date: | 2015-09-16 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of sinapyl alcohol bound monolignol 4-O-methyltransferase at 1.60 Angstroms resolution To Be Published
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6IX8
| The structure of LepI C52A in complex with SAM and its substrate analogue | Descriptor: | (1R,2R,4aS,8S,8aR)-2,8-dimethyl-5'-phenyl-4a,5,6,7,8,8a-hexahydro-2H,2'H-spiro[naphthalene-1,3'-pyridine]-2',4'(1'H)-dione, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J. | Deposit date: | 2018-12-09 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.659 Å) | Cite: | Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11, 2019
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6IX5
| The structure of LepI complex with SAM and its substrate analogue | Descriptor: | 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ... | Authors: | Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J. | Deposit date: | 2018-12-09 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11, 2019
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6IX3
| The structure of LepI complex with SAM | Descriptor: | CHLORIDE ION, O-methyltransferase lepI, S-ADENOSYLMETHIONINE | Authors: | Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J. | Deposit date: | 2018-12-09 | Release date: | 2019-07-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11, 2019
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6IX9
| The structure of LepI C52A in complex with SAM and leporin C | Descriptor: | (6R,6aS,10S,10aR)-10-methyl-4-phenyl-6-[(1E)-prop-1-en-1-yl]-2,6,6a,7,8,9,10,10a-octahydro-1H-[2]benzopyrano[4,3-c]pyridin-1-one, CHLORIDE ION, GLYCEROL, ... | Authors: | Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J. | Deposit date: | 2018-12-09 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.776 Å) | Cite: | Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11, 2019
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6IX7
| The structure of LepI C52A in complex with SAH and substrate analogue | Descriptor: | 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ... | Authors: | Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J. | Deposit date: | 2018-12-09 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.835 Å) | Cite: | Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem., 11, 2019
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6N5V
| Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine | Descriptor: | 2-(1H-indol-4-yl)ethan-1-amine, Strictosidine synthase | Authors: | Cai, Y, Shao, N, Xie, H, Futamura, Y, Panjikar, S, Liu, H, Zhu, H, Osada, H, Zou, H. | Deposit date: | 2018-11-22 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine to be published
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4I5S
| Structure and function of sensor histidine kinase | Descriptor: | Putative histidine kinase CovS; VicK-like protein | Authors: | Cai, Y. | Deposit date: | 2012-11-28 | Release date: | 2013-03-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains Plos Biol., 11, 2013
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8GNJ
| Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2 | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody-C6 | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2022-08-24 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022
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8GNI
| Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1 | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody C6 | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2022-08-24 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022
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8GQ5
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7DJT
| Human SARM1 inhibitory state bounded with inhibitor dHNN | Descriptor: | NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2020-11-21 | Release date: | 2021-05-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. Elife, 10, 2021
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4GHT
| Crystal structure of EV71 3C proteinase in complex with AG7088 | Descriptor: | 3C proteinase, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | Authors: | Chen, C, Wu, C, Cai, Q, Li, N, Peng, X, Cai, Y, Yin, K, Chen, X, Wang, X, Zhang, R, Liu, L, Chen, S, Li, J, Lin, T. | Deposit date: | 2012-08-08 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr.,Sect.D, 69, 2013
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7PP7
| Thunberia alata 16:0-ACP desaturase | Descriptor: | Acyl-[acyl-carrier-protein] 6-desaturase, FE (III) ION | Authors: | Guy, J.E, Whittle, E, Cai, Y, Chai, J, Lindqvist, Y, Shanklin, J. | Deposit date: | 2021-09-13 | Release date: | 2021-12-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Regioselectivity mechanism of the Thunbergia alata Delta 6-16:0-acyl carrier protein desaturase. Plant Physiol., 188, 2022
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3CPM
| plant peptide deformylase PDF1B crystal structure | Descriptor: | Peptide deformylase, chloroplast, SULFATE ION, ... | Authors: | Rodgers, D.W, Houtz, R.L, Dirk, L.M.A, Schmidt, J.J, Cai, Y. | Deposit date: | 2008-03-31 | Release date: | 2008-07-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture Biochem.J., 413, 2008
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4FVB
| Crystal structure of EV71 2A proteinase C110A mutant | Descriptor: | 2A proteinase, ZINC ION | Authors: | Cai, Q, Muhammad, Y, Liu, W, Gao, Z, Peng, X, Cai, Y, Wu, C, Zheng, Q, Li, J, Lin, T. | Deposit date: | 2012-06-29 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational Plasticity of 2A Proteinase from Enterovirus 71 J.Virol., 87, 2013
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