4N90
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4MXW
| Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab | 分子名称: | Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... | 著者 | Sudhamsu, J, Yin, J.P, Hymowitz, S.G. | 登録日 | 2013-09-26 | 公開日 | 2013-11-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
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7KP7
| asymmetric mTNF-alpha hTNFR1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ... | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021
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7KP8
| asymmetric mTNF-alpha hTNFR1 complex | 分子名称: | 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021
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7KPB
| Human TNF-alpha TNFR1 complex bound to conformationally selective antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ... | 著者 | Fox III, D, Conrady, D.G, Lowe, M, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF Nat Commun, 12, 2021
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7KX0
| Crystal structure of the CD27:CD70 co-stimulatory complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, ... | 著者 | Maben, Z, Liu, W, Mosyak, L, Chaparro-Riggers, J. | 登録日 | 2020-12-02 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex. J.Biol.Chem., 297, 2021
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6MGP
| Structure of human 4-1BB / 4-1BBL complex | 分子名称: | ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | 登録日 | 2018-09-14 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Nat Commun, 9, 2018
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6MKZ
| Crystal structure of murine 4-1BB/4-1BBL complex | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Bitra, A, Zajonc, D.M, Doukov, T. | 登録日 | 2018-09-26 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J. Biol. Chem., 294, 2019
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4GIQ
| Crystal Structure of mouse RANK bound to RANKL | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... | 著者 | Nelson, C.A, Wang, M.W.-H, Fremont, D.H. | 登録日 | 2012-08-08 | 公開日 | 2012-10-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
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6A3V
| Complex structure of human 4-1BB and 4-1BBL | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | 著者 | Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | 登録日 | 2018-06-17 | 公開日 | 2018-10-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.391 Å) | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep, 25, 2018
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4I9X
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6BWV
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4J6G
| CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Liu, W, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-02-11 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
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6CPR
| Crystal structure of 4-1BBL/4-1BB complex in C2 space group | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Aruna, B, Zajonc, D.M. | 登録日 | 2018-03-14 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
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6CU0
| Crystal structure of 4-1BBL/4-1BB (C121S) complex in P21 space group | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | 著者 | Aruna, B, Zajonc, D.M, Doukov, T. | 登録日 | 2018-03-23 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
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4KGQ
| Crystal structure of a human light loop mutant in complex with dcr3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... | 著者 | Liu, W, Zhan, C, Bonanno, J.B, Sampathkumar, P, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | 登録日 | 2013-04-29 | 公開日 | 2013-07-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
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4KGG
| Crystal structure of light mutant2 and dcr3 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... | 著者 | Liu, W, Bonanno, J.B, Zhan, C, Kumar, P.R, Toro, R, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-04-29 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
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3IJ2
| Ligand-receptor structure | 分子名称: | Beta-nerve growth factor, Nerve growth factor receptor (TNFR superfamily, member 16) | 著者 | Feng, D, Garcia, K.C. | 登録日 | 2009-08-03 | 公開日 | 2010-01-12 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J.Mol.Biol., 396, 2010
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3K51
| Crystal Structure of DcR3-TL1A complex | 分子名称: | Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form | 著者 | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | 登録日 | 2009-10-06 | 公開日 | 2010-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011
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3ME4
| Crystal structure of mouse RANK | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Walter, S.W, Liu, C, Zhu, X, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. | 登録日 | 2010-03-31 | 公開日 | 2010-06-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural and Functional Insights of RANKL-RANK Interaction and Signaling. J.Immunol., 2010
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3ME2
| Crystal structure of mouse RANKL-RANK complex | 分子名称: | CHLORIDE ION, SODIUM ION, Tumor necrosis factor ligand superfamily member 11, ... | 著者 | Walter, S.W, Liu, C.Z, Zhu, X.K, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. | 登録日 | 2010-03-31 | 公開日 | 2010-06-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and Functional Insights of RANKL-RANK Interaction and Signaling. J.Immunol., 2010
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3MI8
| The structure of TL1A-DCR3 COMPLEX | 分子名称: | TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B | 著者 | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | 登録日 | 2010-04-09 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.951 Å) | 主引用文献 | Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011
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3URF
| Human RANKL/OPG complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 11, soluble form, ... | 著者 | Wang, X.Q, Luan, X.D, Lu, Q.Y. | 登録日 | 2011-11-22 | 公開日 | 2012-07-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin J.Immunol., 189, 2012
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