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4N90

Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody

Summary for 4N90
Entry DOI10.2210/pdb4n90/pdb
DescriptorTumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor ligand superfamily member 10, Fab light chain, ... (5 entities in total)
Functional Keywordsdr5, trail, agonist, antibody, cooperation, clustering, apoptosis-immune system complex, apoptosis/immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: O14763
Membrane; Single-pass type II membrane protein (Potential): P50591
Total number of polymer chains12
Total formula weight242778.05
Authors
Huang, X. (deposition date: 2013-10-18, release date: 2014-09-03)
Primary citationGraves, J.D.,Kordich, J.J.,Huang, T.H.,Piasecki, J.,Bush, T.L.,Sullivan, T.,Foltz, I.N.,Chang, W.,Douangpanya, H.,Dang, T.,O'Neill, J.W.,Mallari, R.,Zhao, X.,Branstetter, D.G.,Rossi, J.M.,Long, A.M.,Huang, X.,Holland, P.M.
Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.
Cancer Cell, 26:177-189, 2014
Cited by
PubMed: 25043603
DOI: 10.1016/j.ccr.2014.04.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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