4GIQ

Crystal Structure of mouse RANK bound to RANKL

Summary for 4GIQ

• Entry DOI: 10.2210/pdb4giq/pdb
• Related: 1D0G 1D4V 1JTZ 3ME4 3QBQ 3k51 3me2
• Descriptor: Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor receptor superfamily member 11A, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: rank, odfr, activation-induced cytokine-receptor, tnfrsf11a, rankl, opgl, tnf-like cytokine, cysteine-rich domain, jelly-roll fold, protein binding-protein binding complex, protein binding/protein binding
• Biological source: Mus musculus (mouse); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cytoplasm. Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted: O35235; Cell membrane ; Single-pass type I membrane protein : O35305
• Total number of polymer chains: 2
• Total formula weight: 38404.94

Authors

Nelson, C.A.,Wang, M.W.-H.,Fremont, D.H. (deposition date: 2012-08-08, release date: 2012-10-24, Last modification date: 2023-09-13)

• Primary citation: Nelson, C.A.,Warren, J.T.,Wang, M.W.,Teitelbaum, S.L.,Fremont, D.H.; RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor.; Structure, 20:1971-1982, 2012; PubMed: 23039992; DOI: 10.1016/j.str.2012.08.030

Experimental method

X-RAY DIFFRACTION (2.7 Å)