5CIR
 
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6A3V
 | | Complex structure of human 4-1BB and 4-1BBL | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | | 著者 | Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | | 登録日 | 2018-06-17 | | 公開日 | 2018-10-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.391 Å) | | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
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4GIQ
 | | Crystal Structure of mouse RANK bound to RANKL | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... | | 著者 | Nelson, C.A, Wang, M.W.-H, Fremont, D.H. | | 登録日 | 2012-08-08 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor.
Structure, 20, 2012
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4I9X
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6BWV
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3K51
 | | Crystal Structure of DcR3-TL1A complex | | 分子名称: | Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form | | 著者 | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | 登録日 | 2009-10-06 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
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6MGP
 | | Structure of human 4-1BB / 4-1BBL complex | | 分子名称: | ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... | | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | | 登録日 | 2018-09-14 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
Nat Commun, 9, 2018
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6MKZ
 | | Crystal structure of murine 4-1BB/4-1BBL complex | | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Bitra, A, Zajonc, D.M, Doukov, T. | | 登録日 | 2018-09-26 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding.
J. Biol. Chem., 294, 2019
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3ME2
 | | Crystal structure of mouse RANKL-RANK complex | | 分子名称: | CHLORIDE ION, SODIUM ION, Tumor necrosis factor ligand superfamily member 11, ... | | 著者 | Walter, S.W, Liu, C.Z, Zhu, X.K, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. | | 登録日 | 2010-03-31 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Insights of RANKL-RANK Interaction and Signaling.
J.Immunol., 2010
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3ME4
 | | Crystal structure of mouse RANK | | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Walter, S.W, Liu, C, Zhu, X, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. | | 登録日 | 2010-03-31 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural and Functional Insights of RANKL-RANK Interaction and Signaling.
J.Immunol., 2010
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3MI8
 | | The structure of TL1A-DCR3 COMPLEX | | 分子名称: | TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B | | 著者 | Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | 登録日 | 2010-04-09 | | 公開日 | 2011-02-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.951 Å) | | 主引用文献 | Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
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4J6G
 | | CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Liu, W, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2013-02-11 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
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7KP7
 | | asymmetric mTNF-alpha hTNFR1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ... | | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | | 登録日 | 2020-11-10 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
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7KP8
 | | asymmetric mTNF-alpha hTNFR1 complex | | 分子名称: | 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A | | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | | 登録日 | 2020-11-10 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
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7KPB
 | | Human TNF-alpha TNFR1 complex bound to conformationally selective antibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ... | | 著者 | Fox III, D, Conrady, D.G, Lowe, M, Ceska, T. | | 登録日 | 2020-11-10 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Nat Commun, 12, 2021
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7KX0
 | | Crystal structure of the CD27:CD70 co-stimulatory complex | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, ... | | 著者 | Maben, Z, Liu, W, Mosyak, L, Chaparro-Riggers, J. | | 登録日 | 2020-12-02 | | 公開日 | 2021-09-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.
J.Biol.Chem., 297, 2021
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4KGQ
 | | Crystal structure of a human light loop mutant in complex with dcr3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... | | 著者 | Liu, W, Zhan, C, Bonanno, J.B, Sampathkumar, P, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2013-04-29 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
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4KGG
 | | Crystal structure of light mutant2 and dcr3 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... | | 著者 | Liu, W, Bonanno, J.B, Zhan, C, Kumar, P.R, Toro, R, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2013-04-29 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
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7MSG
 | | The crystal structure of LIGHT in complex with HVEM and CD160 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen, soluble form,Tumor necrosis factor receptor superfamily member 14, ... | | 著者 | Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C. | | 登録日 | 2021-05-11 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
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4MSV
 | | Crystal structure of FASL and DcR3 complex | | 分子名称: | GLYCEROL, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 6, ... | | 著者 | Liu, W, Ramagopal, U.A, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2013-09-18 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
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4N90
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4MXW
 | | Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab | | 分子名称: | Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... | | 著者 | Sudhamsu, J, Yin, J.P, Hymowitz, S.G. | | 登録日 | 2013-09-26 | | 公開日 | 2013-11-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3QBQ
 | | Crystal structure of extracellular domains of mouse RANK-RANKL complex | | 分子名称: | Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor receptor superfamily member 11A | | 著者 | Ta, H.M, Nguyen, G.T.T, Jin, H.M, Choi, J.K, Park, H, Kim, N.S, Hwang, H.Y, Kim, K.K. | | 登録日 | 2011-01-13 | | 公開日 | 2011-03-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based development of a receptor activator of nuclear factor-kappaB ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis
Proc.Natl.Acad.Sci.USA, 107, 2010
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3QD6
 | | Crystal structure of the CD40 and CD154 (CD40L) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand, Tumor necrosis factor receptor superfamily member 5 | | 著者 | Lee, J.-O, Kim, Y.J, Song, D.H, Kim, H.M, Park, B.S. | | 登録日 | 2011-01-18 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation
J.Biol.Chem., 286, 2011
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3URF
 | | Human RANKL/OPG complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 11, soluble form, ... | | 著者 | Wang, X.Q, Luan, X.D, Lu, Q.Y. | | 登録日 | 2011-11-22 | | 公開日 | 2012-07-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin
J.Immunol., 189, 2012
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