5CIR

Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)

Summary for 5CIR

Entry DOI	10.2210/pdb5cir/pdb
Descriptor	Tumor necrosis factor ligand superfamily member 10, Tumor necrosis factor receptor superfamily member 10A, ZINC ION, ... (5 entities in total)
Functional Keywords	apoptosis, binding and specificity, ligand-receptor complex, tnf receptor family
Biological source	Homo sapiens (Human) More
Cellular location	Membrane ; Single-pass type II membrane protein : P50591 Membrane; Single-pass type I membrane protein: O00220
Total number of polymer chains	6
Total formula weight	94304.86
Authors	Sheriff, S. (deposition date: 2015-07-13, release date: 2017-01-18, Last modification date: 2023-09-27)
Primary citation	Ramamurthy, V.,Yamniuk, A.P.,Lawrence, E.J.,Yong, W.,Schneeweis, L.A.,Cheng, L.,Murdock, M.,Corbett, M.J.,Doyle, M.L.,Sheriff, S. The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. Acta Crystallogr F Struct Biol Commun, 71:1273-1281, 2015 Cited by PubMed: 26457518 DOI: 10.1107/S2053230X15016416 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation