4AW1
Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket
Summary for 4AW1
Entry DOI | 10.2210/pdb4aw1/pdb |
Related | 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2VKI 2XCH 2XCK 4A06 4A07 4AW0 |
Descriptor | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, {(1R)-3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl}propanedioic acid, ... (8 entities in total) |
Functional Keywords | transferase, allosteric regulation, allosteric site, phosphorylation, agc protein kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 36643.61 |
Authors | Schulze, J.O.,Busschots, K.,Lopez-Garcia, L.A.,Lammi, C.,Stroba, A.,Zeuzem, S.,Piiper, A.,Alzari, P.M.,Neimanis, S.,Arencibia, J.M.,Engel, M.,Biondi, R.M. (deposition date: 2012-05-30, release date: 2012-10-03, Last modification date: 2023-12-20) |
Primary citation | Busschots, K.,Lopez-Garcia, L.A.,Lammi, C.,Stroba, A.,Zeuzem, S.,Piiper, A.,Alzari, P.M.,Neimanis, S.,Arencibia, J.M.,Engel, M.,Schulze, J.O.,Biondi, R.M. Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site. Chem.Biol., 19:1152-, 2012 Cited by PubMed: 22999883DOI: 10.1016/J.CHEMBIOL.2012.07.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
Download full validation report