1W1G

Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to DiC4-phosphatidylinositol (3,4,5)-trisphosphate

Summary for 1W1G

Entry DOI	10.2210/pdb1w1g/pdb
Related	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1H
Descriptor	3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE (3 entities in total)
Functional Keywords	transferase, pdk1, phosphoinositide dependent protein kinase 1, pkb, pleckstrin homology domain, inositol phosphate, phosphoinositide, signal transduction, pi3-kinase, pip3 serine/threonine protein kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	18532.54
Authors	Komander, D.,Deak, M.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2004-06-21, release date: 2004-11-19, Last modification date: 2011-07-13)
Primary citation	Komander, D.,Fairservice, A.,Deak, M.,Kular, G.S.,Prescott, A.R.,Downes, C.P.,Safrany, S.T.,Alessi, D.R.,Van Aalten, D.M.F. Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates Embo J., 23:3918-, 2004 Cited by PubMed: 15457207 DOI: 10.1038/SJ.EMBOJ.7600379 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation