1W1H

Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain

Summary for 1W1H

Entry DOI	10.2210/pdb1w1h/pdb
Related	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G
Descriptor	3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywords	pdk1, phosphoinositide dependent protein kinase 1, pkb, pleckstrin homology domain, inositol phosphate, phosphoinositide, signal transduction, pi3-kinase serine/threonine protein kinase, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	4
Total formula weight	72593.75
Authors	Komander, D.,Deak, M.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2004-06-21, release date: 2004-11-19, Last modification date: 2011-07-13)
Primary citation	Komander, D.,Fairservice, A.,Deak, M.,Kular, G.S.,Prescott, A.R.,Downes, C.P.,Safrany, S.T.,Alessi, D.R.,Van Aalten, D.M.F. Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates Embo J., 23:3918-, 2004 Cited by PubMed: 15457207 DOI: 10.1038/SJ.EMBOJ.7600379 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation