1UU8

Structure of human PDK1 kinase domain in complex with BIM-1

Summary for 1UU8

Entry DOI	10.2210/pdb1uu8/pdb
Related	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU9 1UVR
Descriptor	3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywords	protein kinase, pkb, pdk1, inhibitor, ly333531, bisindolyl maleimide, bim-1, diabetes, cancer, transferase, serine/threonine-protein kinase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36844.02
Authors	Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-12-16, release date: 2004-03-04, Last modification date: 2023-12-13)
Primary citation	Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F. Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 Structure, 12:215-, 2004 Cited by PubMed: 14962382 DOI: 10.1016/J.STR.2004.01.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation