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1Z5M

Crystal Structure Of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK1

Summary for 1Z5M
Entry DOI10.2210/pdb1z5m/pdb
Related1h1w 1uu7 1uu8 1uu9 1uvr
Descriptor3-phosphoinositide dependent protein kinase-1, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsprotein inhibitor complex, serine kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: O15530
Total number of polymer chains1
Total formula weight34085.36
Authors
Whitlow, M.,Adler, M. (deposition date: 2005-03-18, release date: 2005-04-19, Last modification date: 2023-08-23)
Primary citationFeldman, R.I.,Wu, J.M.,Polokoff, M.A.,Kochanny, M.J.,Dinter, H.,Zhu, D.,Biroc, S.L.,Alicke, B.,Bryant, J.,Yuan, S.,Buckman, B.O.,Lentz, D.,Ferrer, M.,Whitlow, M.,Adler, M.,Finster, S.,Chang, Z.,Arnaiz, D.O.
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
J.Biol.Chem., 280:19867-19874, 2005
Cited by
PubMed: 15772071
DOI: 10.1074/jbc.M501367200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.17 Å)
Structure validation

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