2VKI

Structure of the PDK1 PH domain K465E mutant

Summary for 2VKI

Entry DOI	10.2210/pdb2vki/pdb
Related	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY
Descriptor	3-PHOPSHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywords	pleckstrin homology, transferase, cancer, diabetes
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	17736.95
Authors	Komander, D.,Bayascas, J.R.,Deak, M.,Alessi, D.R.,van Aalten, D.M.F. (deposition date: 2007-12-19, release date: 2008-05-13, Last modification date: 2023-12-13)
Primary citation	Bayascas, J.R.,Wullschleger, S.,Sakamoto, K.,Garcia-Martinez, J.M.,Clacher, C.,Komander, D.,Van Aalten, D.M.F.,Boini, K.M.,Lang, F.,Lipina, C.,Logie, L.,Sutherland, C.,Chudek, J.A.,Van Diepen, J.A.,Voshol, P.J.,Lucocq, J.M.,Alessi, D.R. Mutation of the Pdk1 Ph Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance. Mol.Cell.Biol., 28:3258-, 2008 Cited by PubMed: 18347057 DOI: 10.1128/MCB.02032-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation