1OKZ
Structure of human PDK1 kinase domain in complex with UCN-01
Summary for 1OKZ
Entry DOI | 10.2210/pdb1okz/pdb |
Related | 1H1W 1OKY 1UU3 1UU7 1UU8 1UU9 1UVR |
Descriptor | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total) |
Functional Keywords | protein kinase, pkb, pdk1, ucn-01, 7-hydroxy staurosporine, inhibitor, transferase, atp-binding, phosphorylation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37014.10 |
Authors | Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-08-01, release date: 2004-07-29, Last modification date: 2023-12-13) |
Primary citation | Komander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F. Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition Biochem.J., 375:255-, 2003 Cited by PubMed: 12892559DOI: 10.1042/BJ20031119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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