1DTT

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)

1DTT の概要

• エントリーDOI: 10.2210/pdb1dtt/pdb
• 関連するPDBエントリー: 1c0t 1c0u 1c1b 1c1c 1dtq 1klm 1rev 1rt1 1rt2 1rt3 1rt4 1rt5 1rt6 1rt7 1rth 1rti 1rtj 1rtv 1vru
• 分子名称: HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-CHLORO-PYRIDYL]-THIOUREA (3 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase aids, non-nucleoside inhibitor, drug design, hydrolase-transferase complex, hydrolase/transferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116348.83

構造登録者

Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K. (登録日: 2000-01-13, 公開日: 2000-04-02, 最終更新日: 2014-11-12)

• 主引用文献: Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K.; Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.; J.Biol.Chem., 275:5633-5639, 2000; PubMed: 10681546; DOI: 10.1074/jbc.275.8.5633

実験手法

X-RAY DIFFRACTION (3 Å)