1KLM

HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152

Summary for 1KLM

• Entry DOI: 10.2210/pdb1klm/pdb
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE, ... (4 entities in total)
• Functional Keywords: aids, hiv-1, endonuclease, rna-directed dna polymerase, hiv-1 reverse transcriptase, bhap u-90152, drug, nucleotidyltransferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116450.56

Authors

Ren, J.,Esnouf, R.M.,Stammers, D.K.,Stuart, D.I. (deposition date: 1997-03-17, release date: 1998-03-18, Last modification date: 2024-04-03)

• Primary citation: Esnouf, R.M.,Ren, J.,Hopkins, A.L.,Ross, C.K.,Jones, E.Y.,Stammers, D.K.,Stuart, D.I.; Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.; Proc.Natl.Acad.Sci.USA, 94:3984-3989, 1997; PubMed: 9108091; DOI: 10.1073/pnas.94.8.3984

Experimental method

X-RAY DIFFRACTION (2.65 Å)