1RT3

AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91

Summary for 1RT3

• Entry DOI: 10.2210/pdb1rt3/pdb
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE (3 entities in total)
• Functional Keywords: nucleotidyltransferase, hiv-1 reverse transcriptase, aids, nucleoside inhibitor, drug resistance mutation
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116391.37

Authors

Ren, J.,Stammers, D.K.,Stuart, D.I. (deposition date: 1998-06-29, release date: 1999-02-16, Last modification date: 2023-08-09)

• Primary citation: Ren, J.,Esnouf, R.M.,Hopkins, A.L.,Jones, E.Y.,Kirby, I.,Keeling, J.,Ross, C.K.,Larder, B.A.,Stuart, D.I.,Stammers, D.K.; 3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.; Proc.Natl.Acad.Sci.USA, 95:9518-9523, 1998; PubMed: 9689112; DOI: 10.1073/pnas.95.16.9518

Experimental method

X-RAY DIFFRACTION (3 Å)