1RT4

HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781

Summary for 1RT4

Entry DOI	10.2210/pdb1rt4/pdb
Descriptor	HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE, ... (5 entities in total)
Functional Keywords	nucleotidyltransferase, hiv-1 reverse transcriptase, aids, nonnucleoside inhibition, drug design
Biological source	HIV-1 M:B_HXB2R More
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains	2
Total formula weight	116424.82
Authors	Ren, J.,Stammers, D.K.,Stuart, D.I. (deposition date: 1998-07-29, release date: 1999-07-29, Last modification date: 2023-08-09)
Primary citation	Ren, J.,Esnouf, R.M.,Hopkins, A.L.,Warren, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K. Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Biochemistry, 37:14394-14403, 1998 Cited by PubMed: 9772165 DOI: 10.1021/bi981309m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation