1RT1
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
Summary for 1RT1
Entry DOI | 10.2210/pdb1rt1/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYL URACIL, ... (4 entities in total) |
Functional Keywords | nucleotidyltransferase, hiv-1 reverse transcriptase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116296.36 |
Authors | Ren, J.,Esnouf, R.,Hopkins, A.,Willcox, B.,Jones, Y.,Ross, C.,Stammers, D.,Stuart, D. (deposition date: 1996-03-16, release date: 1997-04-21, Last modification date: 2023-08-09) |
Primary citation | Hopkins, A.L.,Ren, J.,Esnouf, R.M.,Willcox, B.E.,Jones, E.Y.,Ross, C.,Miyasaka, T.,Walker, R.T.,Tanaka, H.,Stammers, D.K.,Stuart, D.I. Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J.Med.Chem., 39:1589-1600, 1996 Cited by PubMed: 8648598DOI: 10.1021/jm960056x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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