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1RT2

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651

Summary for 1RT2
Entry DOI10.2210/pdb1rt2/pdb
DescriptorHIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL, ... (4 entities in total)
Functional Keywordsnucleotidyltransferase, hiv-1 reverse transcriptase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116358.43
Authors
Ren, J.,Esnouf, R.,Hopkins, A.,Willcox, B.,Jones, Y.,Ross, C.,Stammers, D.,Stuart, D. (deposition date: 1996-03-16, release date: 1997-04-21, Last modification date: 2023-08-09)
Primary citationHopkins, A.L.,Ren, J.,Esnouf, R.M.,Willcox, B.E.,Jones, E.Y.,Ross, C.,Miyasaka, T.,Walker, R.T.,Tanaka, H.,Stammers, D.K.,Stuart, D.I.
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
J.Med.Chem., 39:1589-1600, 1996
Cited by
PubMed: 8648598
DOI: 10.1021/jm960056x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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