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6MII
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Crystal structure of minichromosome maintenance protein MCM/DNA complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ...
Authors:Enemark, E.J, Meagher, M, Epling, L.B.
Deposit date:2018-09-19
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:DNA translocation mechanism of the MCM complex and implications for replication initiation.
Nat Commun, 10, 2019
5XF8
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BU of 5xf8 by Molmil
Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state
Descriptor: Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ...
Authors:Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K.
Deposit date:2017-04-09
Release date:2017-05-03
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
5BK4
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BU of 5bk4 by Molmil
Cryo-EM structure of Mcm2-7 double hexamer on dsDNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (60-mer), strand 1, ...
Authors:Li, H, Yuan, Z, Bai, L.
Deposit date:2017-09-12
Release date:2017-10-25
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6HV9
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BU of 6hv9 by Molmil
S. cerevisiae CMG-Pol epsilon-DNA
Descriptor: Cell division control protein 45, DNA (5'-D(*GP*CP*AP*GP*CP*CP*AP*CP*GP*CP*TP*GP*GP*CP*CP*GP*TP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*AP*CP*GP*GP*CP*CP*AP*GP*CP*GP*TP*GP*GP*CP*TP*GP*C)-3'), ...
Authors:Abid Ali, F, Purkiss, A.G, Cheung, A, Costa, A.
Deposit date:2018-10-10
Release date:2018-12-12
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.98 Å)
Cite:Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.
Nat Commun, 9, 2018
4FDG
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BU of 4fdg by Molmil
Crystal Structure of an Archaeal MCM Filament
Descriptor: Minichromosome maintenance protein MCM, ZINC ION
Authors:Slaymaker, I.M, Fu, Y, Brewster, A.B, Chen, X.S.
Deposit date:2012-05-28
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.
Nucleic Acids Res., 41, 2013
6F0L
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BU of 6f0l by Molmil
S. cerevisiae MCM double hexamer bound to duplex DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (62-MER), DNA replication licensing factor MCM2, ...
Authors:Abid Ali, F, Pye, V.E, Douglas, M.E, Locke, J, Nans, A, Diffley, J.F.X, Costa, A.
Deposit date:2017-11-20
Release date:2017-12-06
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (4.77 Å)
Cite:Cryo-EM structure of a licensed DNA replication origin.
Nat Commun, 8, 2017
6EYC
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BU of 6eyc by Molmil
Re-refinement of the MCM2-7 double hexamer using ISOLDE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ...
Authors:Croll, T.I.
Deposit date:2017-11-11
Release date:2018-06-20
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps.
Acta Crystallogr D Struct Biol, 74, 2018
4R7Z
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BU of 4r7z by Molmil
PfMCM-AAA double-octamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 21, MAGNESIUM ION
Authors:Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J.
Deposit date:2014-08-28
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
4R7Y
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BU of 4r7y by Molmil
Crystal structure of an active MCM hexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J.
Deposit date:2014-08-28
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
3F9V
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BU of 3f9v by Molmil
Crystal Structure Of A Near Full-Length Archaeal MCM: Functional Insights For An AAA+ Hexameric Helicase
Descriptor: Minichromosome maintenance protein MCM
Authors:Chen, X.J, Brewster, A.S, Wang, G.G, Yu, X, Greenleaf, W, Tjajadi, M, Klein, M.
Deposit date:2008-11-14
Release date:2008-12-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase.
Proc.Natl.Acad.Sci.USA, 105, 2008
3F8T
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Crystal structure analysis of a full-length MCM homolog from Methanopyrus kandleri
Descriptor: Predicted ATPase involved in replication control, Cdc46/Mcm family
Authors:Bae, B, Nair, S.K.
Deposit date:2008-11-13
Release date:2009-03-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the Architecture of the Replicative Helicase from the Structure of an Archaeal MCM Homolog.
Structure, 17, 2009
6SKL
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Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1
Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA fork, ...
Authors:Yeeles, J, Baretic, D, Jenkyn-Bedford, M.
Deposit date:2019-08-16
Release date:2020-05-06
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.
Mol.Cell, 78, 2020
8S94
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BU of 8s94 by Molmil
Structure of C-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA helicase MCM8, DNA helicase MCM9, ...
Authors:Li, C, Gao, Y.
Deposit date:2023-03-27
Release date:2023-06-07
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Activity, substrate preference and structure of the HsMCM8/9 helicase.
Nucleic Acids Res., 51, 2023
8S92
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BU of 8s92 by Molmil
Structure of N-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP
Descriptor: DNA helicase MCM8, DNA helicase MCM9
Authors:Li, C, Gao, Y.
Deposit date:2023-03-27
Release date:2023-06-07
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:Activity, substrate preference and structure of the HsMCM8/9 helicase.
Nucleic Acids Res., 51, 2023
8S91
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BU of 8s91 by Molmil
Structure of Walker B mutated MCM8/9 heterohexamer complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA helicase MCM8, DNA helicase MCM9, ...
Authors:Li, C, Gao, Y.
Deposit date:2023-03-27
Release date:2023-06-07
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Activity, substrate preference and structure of the HsMCM8/9 helicase.
Nucleic Acids Res., 51, 2023
7QHS
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BU of 7qhs by Molmil
S. cerevisiae CMGE nucleating origin DNA melting
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
Authors:Lewis, J.S, Sousa, J.S, Costa, A.
Deposit date:2021-12-14
Release date:2022-06-15
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022
6U0M
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BU of 6u0m by Molmil
Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ...
Authors:Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H.
Deposit date:2019-08-14
Release date:2020-03-25
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:DNA unwinding mechanism of a eukaryotic replicative CMG helicase.
Nat Commun, 11, 2020
5U8T
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BU of 5u8t by Molmil
Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications
Descriptor: Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ...
Authors:Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E.
Deposit date:2016-12-15
Release date:2017-02-08
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6SKO
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BU of 6sko by Molmil
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation 2 MCM CTD:ssDNA
Descriptor: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Yeeles, J, Baretic, D, Jenkyn-Bedford, M.
Deposit date:2019-08-16
Release date:2020-05-06
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.
Mol.Cell, 78, 2020
5U8S
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BU of 5u8s by Molmil
Structure of eukaryotic CMG helicase at a replication fork
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ...
Authors:Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E.
Deposit date:2016-12-14
Release date:2017-01-25
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (6.101 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3JC7
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BU of 3jc7 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JA8
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BU of 3ja8 by Molmil
Cryo-EM structure of the MCM2-7 double hexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ...
Authors:Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N.
Deposit date:2015-05-09
Release date:2015-08-05
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
3JC5
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BU of 3jc5 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC6
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BU of 3jc6 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
8W7S
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BU of 8w7s by Molmil
Yeast replisome in state IV
Descriptor: Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ...
Authors:Dang, S, Zhai, Y, Feng, J, Yu, D.
Deposit date:2023-08-31
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (7.39 Å)
Cite:Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023

 

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