4PX9
 
 | | DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | | Deposit date: | 2014-03-22 | | Release date: | 2015-03-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
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4PXA
 | | DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | | Deposit date: | 2014-03-22 | | Release date: | 2015-03-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
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6MII
 | | Crystal structure of minichromosome maintenance protein MCM/DNA complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | | Authors: | Enemark, E.J, Meagher, M, Epling, L.B. | | Deposit date: | 2018-09-19 | | Release date: | 2019-07-24 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | DNA translocation mechanism of the MCM complex and implications for replication initiation.
Nat Commun, 10, 2019
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8E1X
 | | FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | | Descriptor: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | | Authors: | Lei, H.-T, Epling, L.B, Deller, M.C. | | Deposit date: | 2022-08-11 | | Release date: | 2022-11-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J.Med.Chem., 65, 2022
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8UV0
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4R7Y
 | | Crystal structure of an active MCM hexamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | | Deposit date: | 2014-08-28 | | Release date: | 2014-10-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
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4POG
 | | MCM-ssDNA co-crystal structure | | Descriptor: | 30-mer oligo(dT), Cell division control protein 21, ZINC ION | | Authors: | Froelich, C.A, Kang, S, Epling, L.B, Bell, S.P, Enemark, E.J. | | Deposit date: | 2014-02-25 | | Release date: | 2014-04-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.203 Å) | | Cite: | A conserved MCM single-stranded DNA binding element is essential for replication initiation.
Elife, 3, 2014
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4R7Z
 | | PfMCM-AAA double-octamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 21, MAGNESIUM ION | | Authors: | Miller, J.M, Arachea, B.T, Epling, L.B, Enemark, E.J. | | Deposit date: | 2014-08-28 | | Release date: | 2014-10-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Analysis of the crystal structure of an active MCM hexamer.
Elife, 3, 2014
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4POF
 | | PfMCM N-terminal domain without DNA | | Descriptor: | Cell division control protein 21, ZINC ION | | Authors: | Froelich, C.A, Kang, S, Epling, L.B, Bell, S.P, Enemark, E.J. | | Deposit date: | 2014-02-25 | | Release date: | 2014-04-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.648 Å) | | Cite: | A conserved MCM single-stranded DNA binding element is essential for replication initiation.
Elife, 3, 2014
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