1ETH
 
 | | TRIACYLGLYCEROL LIPASE/COLIPASE COMPLEX | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, BETA-MERCAPTOETHANOL, CALCIUM ION, ... | | Authors: | Hermoso, J, Pignol, D, Kerfelec, B, Crenon, I, Chapus, C, Fontecilla-Camps, J.C. | | Deposit date: | 1995-09-13 | | Release date: | 1996-12-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Lipase activation by nonionic detergents. The crystal structure of the porcine lipase-colipase-tetraethylene glycol monooctyl ether complex.
J.Biol.Chem., 271, 1996
|
|
1H4P
 | | Crystal structure of exo-1,3-beta glucanse from Saccharomyces cerevisiae | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUCAN 1,3-BETA-GLUCOSIDASE I/II, GLYCEROL, ... | | Authors: | Ferguson, A.D. | | Deposit date: | 2001-05-11 | | Release date: | 2003-10-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The Er Protein Folding Sensor Udp-Glucose Glycoprotein:Glucosyltransferase Modifies Substrates Distant to Local Changes in Glycoprotein Conformation.
Nat.Struct.Mol.Biol., 11, 2004
|
|
4BDV
 | | CRYSTAL STRUCTURE OF A TRUNCATED B-DOMAIN HUMAN FACTOR VIII | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Svensson, L.A, Thim, L, Olsen, O.H, Nicolaisen, E.M. | | Deposit date: | 2012-10-08 | | Release date: | 2013-05-15 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.98 Å) | | Cite: | Evaluation of the Metal Binding Sites in a Recombinant Coagulation Factor Viii Identifies Two Sites with Unique Metal Binding Properties.
Biol.Chem., 394, 2013
|
|
4EXN
 | | Crystal structure of mouse Interleukin-34 | | Descriptor: | Interleukin-34, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | | Deposit date: | 2012-04-30 | | Release date: | 2012-05-30 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
|
|
4F8X
 | | Penicillium canescens endo-1,4-beta-xylanase XylE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Endo-1,4-beta-xylanase, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Polyakov, K.M, Trofimov, A.A, Fedorova, T.V, Koroleva, O.V, Maisuradze, I.G, Chulkin, A.M, Vavilova, E.A, Benevolenskii, S.V. | | Deposit date: | 2012-05-18 | | Release date: | 2012-05-30 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: |
|
|
4GZT
 | | N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with oseltamivir carboxylate | | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhu, X, Wilson, I.A. | | Deposit date: | 2012-09-06 | | Release date: | 2012-10-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
|
|
4HJ1
 | |
4J4P
 | | The complex of human IgE-Fc with two bound Fab fragments | | Descriptor: | Ig epsilon chain C region, Immunoglobulin G Fab Fragment Heavy Chain, Immunoglobulin G Fab Fragment Light Chain, ... | | Authors: | Drinkwater, N, Sutton, B.J. | | Deposit date: | 2013-02-07 | | Release date: | 2014-03-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Human immunoglobulin E flexes between acutely bent and extended conformations.
Nat.Struct.Mol.Biol., 21, 2014
|
|
5A63
 | | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | | Deposit date: | 2015-06-24 | | Release date: | 2015-08-05 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
|
|
5LHD
 | | Structure of glycosylated human aminopeptidase N | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Recacha, R, Mudgal, G, Santiago, C, Casasnovas, J.M. | | Deposit date: | 2016-07-11 | | Release date: | 2017-04-05 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Sci Rep, 7, 2017
|
|
5O32
 | | The structure of complement complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.20620907647 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
|
|
5X0M
 | | Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, ... | | Authors: | Shen, H, Zhou, Q, Pan, X, Li, Z, Wu, J, Yan, N. | | Deposit date: | 2017-01-21 | | Release date: | 2017-03-08 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.
Science, 355, 2017
|
|
5XJY
 | | Cryo-EM structure of human ABCA1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette sub-family A member 1, ... | | Authors: | Qian, H.W, Yan, N, Gong, X. | | Deposit date: | 2017-05-04 | | Release date: | 2017-06-07 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the Human Lipid Exporter ABCA1.
Cell, 169, 2017
|
|
5XSY
 | | Structure of the Nav1.4-beta1 complex from electric eel | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | | Authors: | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | | Deposit date: | 2017-06-15 | | Release date: | 2017-08-09 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of the Nav1.4-beta 1 Complex from Electric Eel.
Cell, 170, 2017
|
|
6IDF
 | | Cryo-EM structure of gamma secretase in complex with a Notch fragment | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y. | | Deposit date: | 2018-09-09 | | Release date: | 2018-12-26 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
|
|
6IYC
 | | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | | Deposit date: | 2018-12-14 | | Release date: | 2019-01-23 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
|
|
6LQG
 | | Human gamma-secretase in complex with small molecule Avagacestat | | Descriptor: | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | | Deposit date: | 2020-01-13 | | Release date: | 2021-01-27 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
|
|
6LR4
 | | Molecular basis for inhibition of human gamma-secretase by small molecule | | Descriptor: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | | Deposit date: | 2020-01-15 | | Release date: | 2021-01-27 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
|
|
6XUT
 | | Crystallographic structure of oligosaccharide dehydrogenase from Pycnoporus cinnabarinus, ligand-free form | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Cerutti, G, Savino, C, Montemiglio, L.C, Sciara, G, Vallone, B. | | Deposit date: | 2020-01-21 | | Release date: | 2021-02-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose.
Biotechnol Biofuels, 14, 2021
|
|
6Y3C
 | | Human COX-1 Crystal Structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Prostaglandin G/H synthase 1, ... | | Authors: | Miciaccia, M, Belviso, B.D, Iaselli, M, Ferorelli, S, Perrone, M.G, Caliandro, R, Scilimati, A. | | Deposit date: | 2020-02-18 | | Release date: | 2020-02-26 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.361 Å) | | Cite: | Three-dimensional structure of human cyclooxygenase (hCOX)-1.
Sci Rep, 11, 2021
|
|
7C9I
 | | Human gamma-secretase in complex with small molecule L-685,458 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2020-06-05 | | Release date: | 2021-01-27 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
|
|
7D8X
 | | CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | | Deposit date: | 2020-10-11 | | Release date: | 2021-01-27 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
|
|
7E7I
 | | Cryo-EM structure of human ABCA4 in the apo state | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | | Authors: | Xie, T, Zhang, Z.K, Gong, X. | | Deposit date: | 2021-02-26 | | Release date: | 2021-06-30 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of substrate recognition and translocation by human ABCA4.
Nat Commun, 12, 2021
|
|
7E7O
 | | Cryo-EM structure of human ABCA4 in NRPE-bound state | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | | Authors: | Xie, T, Zhang, Z.K, Gong, X. | | Deposit date: | 2021-02-26 | | Release date: | 2021-06-30 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of substrate recognition and translocation by human ABCA4.
Nat Commun, 12, 2021
|
|
7E7Q
 | | Cryo-EM structure of human ABCA4 in ATP-bound state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Xie, T, Zhang, Z.K, Gong, X. | | Deposit date: | 2021-02-26 | | Release date: | 2021-06-30 | | Last modified: | 2021-07-07 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of substrate recognition and translocation by human ABCA4.
Nat Commun, 12, 2021
|
|
