PDB: 270 件ウェブページステータス検索Chemie searchBIRD

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7W3C	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED0_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3A	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3K	Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD4_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3M	Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD5_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-18 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3I	Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-18 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3R	USP34 catalytic domain 分子名称: Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION 著者 Xu, G.L, Ming, Z.H. 登録日 2021-11-26 公開日 2022-06-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol., 434, 2022
7W3U	USP34 catalytic domain in complex with UbPA 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION, ... 著者 Xu, G.L, Ming, Z.H. 登録日 2021-11-26 公開日 2022-06-01 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol., 434, 2022
7XHH	High-resolution X-ray cocrystal structure of USP7 in complex with X4 分子名称: 3-[4-(aminomethyl)phenyl]-6-[[1-[[2-chloranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]-4-oxidanyl-piperidin-4-yl]methyl]-2-methyl-pyrazolo[4,3-d]pyrimidin-7-one, Ubiquitin carboxyl-terminal hydrolase 7 著者 Sun, H.B, Wen, X.A. 登録日 2022-04-08 公開日 2023-04-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 High-resolution X-ray cocrystal structure of USP7 in complex with X4 To Be Published
7XHK	High-resolution X-ray cocrystal structure of USP7 in complex with LX04-46 分子名称: Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[[4-[6-[[1-[[2-chloranyl-4-(furan-2-yl)phenyl]methyl]-4-oxidanyl-piperidin-4-yl]methyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-3-yl]phenyl]methyl]methanamide 著者 Sun, H.B, Wen, X.A. 登録日 2022-04-08 公開日 2023-06-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 High-resolution X-ray cocrystal structure of USP7 in complex with LX04-46 To Be Published
7YXX	Cryo-EM structure of USP9X 分子名称: Probable ubiquitin carboxyl-terminal hydrolase FAF-X 著者 Deme, J.C, Halabelian, L, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) 登録日 2022-02-16 公開日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of USP9X To Be Published
7YXY	Cryo-EM structure of USP9X, local refinement of monomer 分子名称: Probable ubiquitin carboxyl-terminal hydrolase FAF-X 著者 Deme, J.C, Halabelian, L, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) 登録日 2022-02-16 公開日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM structure of USP9X To Be Published
3HGM	Universal Stress Protein TeaD from the TRAP transporter TeaABC of Halomonas elongata 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Universal Stress Protein TeaD 著者 Schweikhard, E.S, Kuhlmann, S.I, Ziegler, C.M. 登録日 2009-05-14 公開日 2010-03-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and function of the universal stress protein TeaD and its role in regulating the ectoine transporter TeaABC of Halomonas elongata DSM 2581(T) Biochemistry, 49, 2010
8ITP	Crystal structure of USP47 catalytic domain complex with ubiquitin 分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 47, ZINC ION 著者 Kim, E.E, Shin, S.C. 登録日 2023-03-22 公開日 2024-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and functional characterization of USP47 reveals a hot spot for inhibitor design. Commun Biol, 6, 2023
4MEL	Crystal Structure of the human USP11 DUSP-UBL domains 分子名称: Ubiquitin carboxyl-terminal hydrolase 11 著者 Harper, S, Gratton, H.E, Cornaciu, I, Oberer, M, Scott, D.J, Emsley, J, Dreveny, I. 登録日 2013-08-27 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry, 53, 2014
4MEM	Crystal Structure of the rat USP11 DUSP-UBL domains 分子名称: Ubiquitin carboxyl-terminal hydrolase 11 著者 Harper, S, Gratton, H.E, Cornaciu, I, Oberer, M, Scott, D.J, Emsley, J, Dreveny, I. 登録日 2013-08-27 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry, 53, 2014
8A9J	Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323 (consensus reconstruction) 分子名称: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... 著者 Rennie, M.L, Walden, H. 登録日 2022-06-28 公開日 2022-10-12 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
8A9K	Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) 分子名称: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... 著者 Rennie, M.L, Walden, H. 登録日 2022-06-28 公開日 2022-10-12 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
5XVE	Crystal structure of human USP2 C276S mutant in complex with ubiquitin 分子名称: Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, ZINC ION 著者 Chou, C.Y, Tang, H.C. 登録日 2017-06-27 公開日 2018-02-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8, 2018
6AQR	SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin 分子名称: Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ... 著者 Morrow, M.E, Morgan, M.T, Wolberger, C. 登録日 2017-08-21 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins. EMBO Rep., 19, 2018
7AY1	Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI 分子名称: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... 著者 Rennie, M.L, Arkinson, C, Walden, H. 登録日 2020-11-10 公開日 2021-03-24 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
6LVS	USP14 catalytic domain mutant C114S 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, FORMIC ACID, ... 著者 Lin, H.C, Lin, T.H, Chou, C.Y. 登録日 2020-02-04 公開日 2020-03-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 USP14 catalytic domain mutant C114S To Be Published
7SVS	Crystal structure analysis of the G73A mutant of Superoxide Dismutase from Trichoderma reesei 分子名称: MANGANESE (II) ION, Superoxide dismutase 著者 Mendoza Rengifo, E, Ferreira Jr, J.R, Garratt, C.R. 登録日 2021-11-19 公開日 2022-02-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Unexpected plasticity of the quaternary structure of iron-manganese superoxide dismutases. J.Struct.Biol., 214, 2022
5TXK	CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN 分子名称: 1,2-ETHANEDIOL, Polyubiquitin-B, SULFATE ION, ... 著者 Bader, G, Weiss-Puxbaum, A, Zoephel, A. 登録日 2016-11-17 公開日 2018-05-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J. Cell. Sci., 131, 2018
5K19	Crystal structure of WD repeat-containing protein 20 分子名称: GLYCEROL, SULFATE ION, WD repeat-containing protein 20 著者 Li, H, D'Andrea, A.D, Zheng, N. 登録日 2016-05-17 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016
6H4K	Structure of the Usp25 C-terminal domain 分子名称: CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 25 著者 Klemm, T.A, Sauer, F, Kisker, C. 登録日 2018-07-21 公開日 2019-03-27 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol.Cell, 74, 2019

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