5XVE
Crystal structure of human USP2 C276S mutant in complex with ubiquitin
Summary for 5XVE
Entry DOI | 10.2210/pdb5xve/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, ZINC ION, ... (4 entities in total) |
Functional Keywords | ubiquitin specific protease for anticancer target, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm . Isoform 4: Nucleus : O75604 Ubiquitin: Cytoplasm : P62992 |
Total number of polymer chains | 2 |
Total formula weight | 49835.83 |
Authors | Chou, C.Y.,Tang, H.C. (deposition date: 2017-06-27, release date: 2018-02-28, Last modification date: 2023-11-22) |
Primary citation | Chuang, S.J.,Cheng, S.C.,Tang, H.C.,Sun, C.Y.,Chou, C.Y. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8:3102-3102, 2018 Cited by PubMed: 29449607DOI: 10.1038/s41598-018-21476-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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