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5XVE

Crystal structure of human USP2 C276S mutant in complex with ubiquitin

Summary for 5XVE
Entry DOI10.2210/pdb5xve/pdb
DescriptorUbiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, ZINC ION, ... (4 entities in total)
Functional Keywordsubiquitin specific protease for anticancer target, hydrolase
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm . Isoform 4: Nucleus : O75604
Ubiquitin: Cytoplasm : P62992
Total number of polymer chains2
Total formula weight49835.83
Authors
Chou, C.Y.,Tang, H.C. (deposition date: 2017-06-27, release date: 2018-02-28, Last modification date: 2023-11-22)
Primary citationChuang, S.J.,Cheng, S.C.,Tang, H.C.,Sun, C.Y.,Chou, C.Y.
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
Sci Rep, 8:3102-3102, 2018
Cited by
PubMed: 29449607
DOI: 10.1038/s41598-018-21476-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.24 Å)
Structure validation

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