PDB: 539 resultsInfo pagesStatus searchChemie searchBIRD

---

5WAT	Corynebacterium glutamicum Full length Homoserine kinase Descriptor: HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ... Authors: Petit, C, Ronning, D.R. Deposit date: 2017-06-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.141 Å) Cite: Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
5WAS	Corynebacterium glutamicum Hydrolyzed Homoserine kinase Descriptor: Homoserine kinase, PHOSPHATE ION Authors: Petit, C, Ronning, D.R. Deposit date: 2017-06-27 Release date: 2018-02-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
6CYZ	Mycobacterial homoserine kinase ThrB in complex with AMPPNP Descriptor: CHLORIDE ION, Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Li, J, Korotkov, K.V. Deposit date: 2018-04-07 Release date: 2018-04-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Mycobacterial homoserine kinase ThrB To Be Published
3HUL	Structure of putative homoserine kinase thrB from Listeria monocytogenes Descriptor: Homoserine kinase, SULFATE ION Authors: Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2009-06-15 Release date: 2009-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Structure of putative homoserine kinase thrB from Listeria monocytogenes To be published
6KNW	THRb mutation with a novel agonist Descriptor: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta Authors: Yao, B.Q, Li, Y. Deposit date: 2019-08-07 Release date: 2019-10-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KNV	THRb mutation with a novel agonist Descriptor: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta Authors: Yao, B.Q, Li, Y. Deposit date: 2019-08-07 Release date: 2019-10-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KKE	THRb mutation with a novel agonist Descriptor: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta Authors: Yao, B.Q, Li, Y. Deposit date: 2019-07-25 Release date: 2019-10-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.577 Å) Cite: Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KNU	THRb mutation with a novel agonist Descriptor: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta Authors: Yao, B.Q, Li, Y. Deposit date: 2019-08-07 Release date: 2019-10-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
5NHU	HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, AGAP008004-PA, Prothrombin, ... Authors: Ripoll-Rozada, J, Pereira, P.J.B. Deposit date: 2017-03-22 Release date: 2017-06-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. J. Biol. Chem., 292, 2017
7PHX	Tsetse thrombin inhibitor in complex with human alpha-thrombin - acid-stable sulfotyrosine analogue Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin heavy chain, ... Authors: Pereira, P.J.B, Ripoll-Rozada, J, Calisto, B.M. Deposit date: 2021-08-18 Release date: 2021-10-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues. Chem.Commun.(Camb.), 57, 2021
7SR9	Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... Authors: Di Cera, E, Ruben, E.A, Chen, Z. Deposit date: 2021-11-08 Release date: 2021-12-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The active site region plays a critical role in Na + binding to thrombin. J.Biol.Chem., 298, 2022
8KME	CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770. Descriptor: N-ACETYLHIRUDIN, SEL2770, SODIUM ION, ... Authors: Mochalkin, I, Tulinsky, A. Deposit date: 1999-03-21 Release date: 1999-03-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding. Acta Crystallogr.,Sect.D, 55, 1999
6KKB	A novel agonist of THRb Descriptor: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta Authors: Yao, B.Q, Li, Y. Deposit date: 2019-07-24 Release date: 2019-10-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
7WMJ	A novel chemical derivative(71) of THRB agonist Descriptor: 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-14 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WLX	A novel chemical derivative(53) of THRB agonist Descriptor: 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-14 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMO	A novel chemical derivative(92) of THRB agonist Descriptor: 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-15 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMG	A novel chemical derivative(52) of THRB agonist Descriptor: 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-14 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMN	A novel chemical derivative(89) of THRB agonist Descriptor: 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-15 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WML	A novel chemical derivative(85) of THRB agonist Descriptor: 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-15 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMH	A novel chemical derivative(56) of THRB agonist Descriptor: 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 Authors: Yao, B.Q, Li, Y. Deposit date: 2022-01-14 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
8TQS	Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker. Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... Authors: Krishnaswamy, S, Kumar, S. Deposit date: 2023-08-08 Release date: 2024-05-01 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.207 Å) Cite: Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nat Commun, 15, 2024
8UF7	Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin Descriptor: POmAb Heavy Chain, POmAb Light Chain, Prothrombin Authors: Kumar, S, Summers, B, Basore, K, Pozzi, N. Deposit date: 2023-10-03 Release date: 2024-02-14 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody. Blood, 143, 2024
4YES	Thrombin in complex with (S)-(4-chloro-2-((1-(5-methyl-1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin, ... Authors: Orth, P. Deposit date: 2015-02-24 Release date: 2015-06-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement. Acs Med.Chem.Lett., 6, 2015
2HPP	Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin Descriptor: ALPHA-THROMBIN HEAVY CHAIN, ALPHA-THROMBIN LIGHT CHAIN, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ... Authors: Tulinsky, A, Padmanabhan, K. Deposit date: 1993-04-28 Release date: 1994-01-31 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. Biochemistry, 32, 1993
2SPT	DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTHROMBIN, STRONTIUM ION Authors: Tulinsky, A. Deposit date: 1994-02-01 Release date: 1994-05-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1. Biochemistry, 33, 1994

 

12345678910111213141516>