5NHU

HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT

Summary for 5NHU

• Entry DOI: 10.2210/pdb5nhu/pdb
• Descriptor: Prothrombin, AGAP008004-PA, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: blood clotting, anticoagulant, thrombin, inhibitor, hydrolase
• Biological source: Anopheles gambiae (African malaria mosquito); More
• Total number of polymer chains: 9
• Total formula weight: 129176.84

Authors

Ripoll-Rozada, J.,Pereira, P.J.B. (deposition date: 2017-03-22, release date: 2017-06-14, Last modification date: 2024-01-17)

• Primary citation: Pirone, L.,Ripoll-Rozada, J.,Leone, M.,Ronca, R.,Lombardo, F.,Fiorentino, G.,Andersen, J.F.,Pereira, P.J.B.,Arca, B.,Pedone, E.; Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.; J. Biol. Chem., 292:12632-12642, 2017; PubMed: 28592490; DOI: 10.1074/jbc.M117.788042

Experimental method

X-RAY DIFFRACTION (1.45 Å)