5NHU

HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005509	molecular_function	calcium ion binding
A	0006508	biological_process	proteolysis
A	0007596	biological_process	blood coagulation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0007596	biological_process	blood coagulation
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005509	molecular_function	calcium ion binding
C	0006508	biological_process	proteolysis
C	0007596	biological_process	blood coagulation
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0007596	biological_process	blood coagulation
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
I	0005576	cellular_component	extracellular region
I	0035821	biological_process	modulation of process of another organism
I	0090729	molecular_function	toxin activity
I	0140678	molecular_function	molecular function inhibitor activity
J	0005576	cellular_component	extracellular region
J	0035821	biological_process	modulation of process of another organism
J	0090729	molecular_function	toxin activity
J	0140678	molecular_function	molecular function inhibitor activity
K	0005576	cellular_component	extracellular region
K	0035821	biological_process	modulation of process of another organism
K	0090729	molecular_function	toxin activity
K	0140678	molecular_function	molecular function inhibitor activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU359-CYS364

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP519-VAL530

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	9
Details	Region: {"description":"Blocks active site cleft of host thrombin in a reverse direction compared to substrates","evidences":[{"source":"PubMed","id":"28592490","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NHU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	12
Details	Region: {"description":"Blocks exosite I of host thrombin","evidences":[{"source":"PubMed","id":"28592490","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NHU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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