8TQS
Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker.
Summary for 8TQS
Entry DOI | 10.2210/pdb8tqs/pdb |
Descriptor | DNA (30-MER), Thrombin heavy chain, Prothrombin, ... (9 entities in total) |
Functional Keywords | human thrombin, dna aptamer, dabigatran, blood clotting |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 44937.87 |
Authors | Krishnaswamy, S.,Kumar, S. (deposition date: 2023-08-08, release date: 2024-05-01, Last modification date: 2024-05-22) |
Primary citation | Yu, H.,Kumar, S.,Frederiksen, J.W.,Kolyadko, V.N.,Pitoc, G.,Layzer, J.,Yan, A.,Rempel, R.,Francis, S.,Krishnaswamy, S.,Sullenger, B.A. Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nat Commun, 15:3977-3977, 2024 Cited by PubMed: 38730234DOI: 10.1038/s41467-024-48211-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.207 Å) |
Structure validation
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