6KNV
THRb mutation with a novel agonist
Summary for 6KNV
Entry DOI | 10.2210/pdb6knv/pdb |
Related | 6KKB |
Descriptor | Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, ... (4 entities in total) |
Functional Keywords | agonist, thyroid hormone receptor, anemia, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30002.73 |
Authors | |
Primary citation | Yao, B.,Wei, Y.,Zhang, S.,Tian, S.,Xu, S.,Wang, R.,Zheng, W.,Li, Y. Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20:489-496, 2019 Cited by PubMed: 31655060DOI: 10.1016/j.isci.2019.10.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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