6KNV
THRb mutation with a novel agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thyroid hormone receptor beta | polymer | 250 | 28300.8 | 1 | UniProt (P10828) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 1 group A member 2,c-erbA-2,c-erbA-beta |
| 2 | B (C) | Nuclear receptor coactivator 2 | polymer | 11 | 1349.6 | 1 | UniProt (Q15596) | Homo sapiens (Human) | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid | non-polymer | 352.3 | 1 | Chemie (8HO) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 211 - 460 (UniProt: P10828)
| PDB | External Database | Details |
|---|---|---|
| Trp 438 | Arg 438 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29650.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 352.3 | |
| All* | Total formula weight | 30002.7 |
